A simple, rapid, accurate, precise and economical reverse phase high performance liquid chromato graphic method has been developed for simultaneous estimation of Doxophylline and Montelukast sodium. The separation of drugs was achieved on Inertsil Ph-3 column (250 mmx4.6 mm id, 5 μm particle size) with mobile phase of Ammonium acetate 0.05milimolar and Glacial acetic acid buffer (pH 3.5): Metha...

A simple and precise HPLC method was developed for estimation of Montelukast sodium (MTKT) and Levocetirizine dihydrochloride (LCTZ) in pure and pharmaceutical dosage form. HPLC separation was achieved with a Phenomenex (Torrance, CA) C18 column (250 mm × 4.6 mm id, 5 μm particle size) as stationary phase and methanol: Trichloroacetic acid: Acetonitril (90:5:5, v/v/v) as eluent, at a flow rate ...

BACKGROUND Montelukast sodium, a potent, oral, specific leukotriene-receptor antagonist, has demonstrated clinical efficacy in the treatment of chronic asthma. Loratadine, a selective histamine type 1 (H(1))-receptor antagonist, has demonstrated antiallergic properties. Leukotriene-receptor antagonists given concomitantly with H(1)-receptor antagonists have been shown to have additive effects i...

A rapid, simple, sensitive and selective analytical method was developed by using reverse phase ultra performance liquid chromatographic technique for the simultaneous estimation of bambuterol hydrochloride and montelukast sodium in combined tablet dosage form. The developed method is superior in technology to conventional high performance liquid chromatography with respect to speed, resolution...

The present study aims to formulate mouth dissolving tablets of montelukast sodium by direct compression method for the faster action, better absorption and improvement bioavailability drug in management Asthma. Total six formulations were developed with varying concentrations combination Crosspovidone Sodium starch glycolate as super disintegrating agents. prepared method. MDT evaluated variou...

An accurate, specific and precise assay level gradient reverse-phase high-performance liquid chromatographic method was developed for simultaneous determination of montelukast sodium and bambuterol hydrochloride in tablet dosage form. An inertsil ODS C-18, 5 mum column having 250x4.6 mm I.D. in gradient mode, with mobile phase A, containing 0.025 M sodium phosphate buffer: methanol (85:15) and ...

Eosinophilic cystitis (EC) is a rare inflammatory disorder. We herein report a case of EC in an asthmatic female patient who had a recent exacerbation with none known allergen. She was administered montelukast sodium orally for four weeks and received complete remission. This medication was successfully discontinued after a three-month follow up period. This case report about successful treatme...

This research paper describes simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method for the simultaneous determination of Montelukast sodium and Bambuterol hydrochloride in combined dosage form. The sample was analyzed by reverse phase C18 column (Phenomenex C18, 5μ, 250mm x 4.6mm) as stationary phase; methanol: acetonitrile : 1% trichloroacetic acid i...

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

Direct drug determination without any pervious treatment steps is the most environmentally friendly method of analysis. Traditional analysis methods usually involve a pre-treatment step before analysis and this consumes time and organic solvents. This work describes direct potentiometric method by using ion selective electrode to determine Montelukast Sodium in its pure drug substance and in ta...