The genotoxic effect of epirubicin, a semisynthetic anthracycline antibiotic which has been used as an anticancer drug, was investigated in vivo on bone marrow cells of Swiss albino mice using the micronucleus test. To determine the incidence of micronuclei, mice were injected intraperitoneally with the drug at single doses of 4, 6, 8, and 10 mg/kg body weight. Then, bone marrow was sampled 18,...

BOZZINI, C. E., M. E. BARRIO RENDO, F. C. H. DEVOTO, AND C. E. EPPER. Studies on medullary and extramedullary erythropoiesis in the adult mouse. Am. J. Physiol. 219(3) : 724-728. 1970.Splenic and marrow erythropoiesis was compared in the mouse following stimulation by hypoxia, bleeding, or injections of erythropoietin or depression of erythropoiesis by transfusion. The effect of splenectomy on ...

Background: The search for potent radioprotective agents for the amelioration of radiation side effect is an important aim in radiobiology. The present study aimed to evaluate the effects of curcumin and seleno-L-methionine against radiation-induced micronucleus formation in rat bone marrow.Methods: In total, 40 male rats were divided into 8 groups (n=5 each), including control, curcumin or sel...

Chronic myelomonocytic leukaemia (CMML) is a disease that borders between myelodyplastic syndrome (MDS) and myeloproliferative neoplasia (MPN). It progressive condition: about 20% of CMML patients progress to secondary acute myeloid (sAML), which has very poor prognosis. In all cases, normal bone marrow function compromised with resulting depletion circulating erythrocytes platelets. We modelle...

Background: Previous investigations have revealed, cimetidine, a histamine H2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. In this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine H2-receptor antagonists, was investigated. Materials and Methods : Balb/c m...

Cysteamine or 2-mercaptoethylamine (MEA) is an aminothiol with a well-known radioprotective action. No specific information is available in the literature about the possible chemoprotective action of MEA against genotoxic chemical agents. This paper presents the results of studies on the ability of MEA to protect mouse bone marrow polychromatic erythrocytes against the induction of micronuclei ...

In previous communications, it was demonstrated that normal rabbit bone marrow cells are capable of reacting with antigens in vitro (1-3). After administration of an antigen, the bone marrow cells lose the capacity to react to this particular antigen, whereas their reactivity to other antigens is not impaired. I t was demonstrated (4, S) that spleen cells of irradiated rabbits injected with hom...

Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes from bone marrow. The extract w...

The compound 2-furyl-1-nitroethene (G-0) has been tested to determine its ability to induce clastogenic or aneugenic effects in vivo, through the induction of micronucleated polychromatic erythrocytes (MNPCE) in mouse bone marrow. Groups of five CD-1 male mice were administered once intraperitoneally at a dose range of 5-20 mg/kg and bone marrow was sampled at 24 and 48 h after the treatment. G...