Baclofen is a synthetic derivative of GABA and used as muscle relaxant or antispasmodic agent. It in the management various spasticity resulting from conditions such cerebral palsy, spinal cord injuries, stroke. The reported potential adverse effects following overdose are marked impairment consciousness, acute kidney injury, seizures, coma, respiratory failure. Since there no specific antidote...

BACKGROUND Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) ...

celiac disease can be accompanied with multiorgan involvement in addition to gastro-intestinal involvement. a 16-year-old young man - known case of celiac disease - was admitted because of exacerbation of gastrointestinal complaints. during further investigations, hypothyroidism and membranous glomerulonephritis were discovered. the patient was improved with a gluten-free diet and specific trea...

Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of alpha-haloacids, including dichloroacetic acid (DCA), and the penultimate step in the tyrosine degradation pathway. DCA is a rodent carcinogen and a common drinking water contaminant. DCA also causes multiorgan toxicity in rodents and dogs. The objective of this study was to determine the expression and activit...

W ITH THE INCREASING complexity of patients undergoing transplantation, the transplant services are called on to evaluate a variety of patients with concomitant metabolic derangements. Optimal function of an allograft and management of these patients in the posttransplant period may require consideration of multiorgan transplantation. The concept of multiorgan transplantation has become a reali...

In the drive to develop drugs with well-characterized and clinically monitorable safety profiles, there is incentive to expand the repertoire of safety biomarkers for toxicities without routine markers or premonitory detection. Biomarkers in blood are pursued because of specimen accessibility, opportunity for serial monitoring, quantitative measurement, and the availability of assay platforms. ...