Myelinated and unmyelinated serotonin-containing axons were demonstrated in the medial forebrain bundle of rats and monkeys with an antibody against serotonin (5-HT) conjugated to hemocyanin. The level of 5-HT in the brain was increased by pretreatment of animals with pargyline and L-tryptophan. The addition of nickel salts to the diaminobenzidine-peroxidase reaction mixture increased the inten...

A surgical technique has been developed for the correction of established unilateral palsy in man. A long (20 cm or more) sural nerve graft is anastomosed to a facial nerve branch on the unaffected side and its distal end left lying free in the cheek of the affected side. After regeneration times of 5.5-14.5 months, the distal end of the graft is joined to a free (pectoralis minor) muscle graft...

Myofascial trigger points (MTrPs) are common causes for chronic pain. Myelinated afferents were considered to be related with muscular pain, and our clinical researches indicated they might participate in the pathology of MTrPs. Here, we applied myofascial trigger spots (MTrSs, equal to MTrPs in human) of rats to further investigate role of myelinated afferents. Modified pyridine-silver stainin...

OBJECTIVES Vocal cord palsy seen in some patients with multiple system atrophy may result from neuronopathy of the recurrent laryngeal nerve. METHODS Six controls and six patients with multiple system atrophy, four with and two without vocal cord palsy were studied. The number of myelinated nerve fibres were counted and fibre diameter histograms were established for the motor and sensory divi...

Bilateral anodal block of both cervical vagus nerves of anaesthetized rabbits has been used to assess the relative role of afferent pathways with myelinated fibres (primarily from lung irritant receptors) and with nonmyelinated fibres (from J-receptors) in respiratory responses to some lung conditions. With inhalation of histamine aerosol the increase in breathing frequency is due to myelinated...

Understanding wave propagation in discrete excitable media is challenging because of poorly understood phenomena associated with spatial discreteness [1, 2, 3, 4, 5]. The study of the transmission of nerve impulses along myelinated axons is a paradigmatic example. Myelinated nerve fibers, such as the motor axons of vertebrates, are covered almost everywhere by a thick insulating coat of myelin....

Rapid nerve impulse conduction depends on specialized membrane domains in myelinated nerve, the node of Ranvier, the paranode, and the myelinated internodal region. We report that GPI-linked contactin enables the formation of the paranodal septate-like axo-glial junctions in myelinated peripheral nerve. Contactin clusters at the paranodal axolemma during Schwann cell myelination. Ablation of co...