the effect of nerve growth factor (ngf) on regeneration of rat sciatic nerves in adult rat was studied. the sciatic nerve was cut out across a 6‑mm gap, then the proximal and distal stumps were inserted into the silicone tube chamber. 7s ngf was extracted from submaxillary gland and then was injected into the silicone in experimental group. after seven months nerve was transected and stained wi...

background: peripheral nerves may be damaged during an injury and its current standard treatment is using an autologous nerve. objectives: the purpose of this experimental study is to evaluate and compare the histological results of nerve regeneration after using the eggshell membrane (esm) guidance channel with autograft. materials and methods: thirty adult male rats were divided into three ex...

Advances in brain connectomics set the need for detailed knowledge of functional properties of myelinated and non-myelinated (if present) axons in specific white matter pathways. The corpus callosum (CC), a major white matter structure interconnecting brain hemispheres, is extensively used for studying CNS axonal function. Unlike another widely used CNS white matter preparation, the optic nerve...

The damage of white matter, primarily myelinated fibers, in the central nervous system (CNS) of temporal lobe epilepsy (TLE) patients has been recently reported. However, limited data exist addressing the types of changes that occur to myelinated fibers inside the hippocampus as a result of TLE. The current study was designed to examine this issue in a lithium-pilocarpine rat model. Investigate...

The work concerns the multiscale modeling of a nerve fascicle myelinated axons. We present rigorous derivation macroscopic bidomain model describing behavior electric potential in based on FitzHugh–Nagumo membrane dynamics. approach is two-scale convergence machinery combined with method monotone operators.

Unbiased stereological sampling and counting techniques for estimating the total length, total volume and diameter distribution of myelinated nerve fibers in white matter and the total number of synapses in neocortex of human autopsy brains were described. Uniform random sampling of tissues from entire hemisphere was performed. The total volume and total length of myelinated fibers in white mat...

Schizophrenia is believed to result from altered neuronal connectivity and impaired myelination. However, there are few direct evidence for myelin abnormalities in schizophrenia. We performed electron microscopic study of myelinated fibers and oligodendrocytes and morphometric study of myelinated fibers in the prefrontal cortex in gray and white matters in schizophrenia and normal controls. Six...

Previous studies in the hypomyelinating mouse mutant Trembler have suggested that demyelinating axons are smaller in caliber compared to normal axons, and that there are differences in the organization of axonal neurofilaments. In the normal PNS, however, the relationship between neurofilament organization and myelination has not been investigated extensively. In normal axons, only the initial ...