BACKGROUND Quantitative analysis of nanoparticle uptake at the cellular level is critical to nanomedicine procedures. In particular, it is required for a realistic evaluation of their effects. Unfortunately, quantitative measurements of nanoparticle uptake still pose a formidable technical challenge. We present here a method to tackle this problem and analyze the number of metal nanoparticles p...

background: investigation of toxicity of silver nanoparticle, especxially blood toxicity, is necessary because this nanoparticle is used a lot in diffrerent parts of life and invironment. the aime of this is evaluation the effects of silver nanoparticles with different concentrations on blood cells pregnant wistar rats. materials and methods: in this case control study, 30 pregnant rat were div...

Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe(2)O(3) nanoparticles showed high structural quality. The particles showed a homogeneous sp...

Intracranial neoplasia is a significant cause of morbidity and mortality in both human and veterinary patients, and is difficult to treat with traditional therapeutic methods. Cisplatin is a platinum (Pt)-containing chemotherapeutic agent approved by the Food and Drug Administration; however, substantial limitations exist for its application in canine brain tumor treatment due to the difficulty...

The number of reports of nanoparticle CT contrast agents has been growing swiftly over the past 5 years. These nanoparticles can be applied to produce long-lived CT contrast in the blood vessels and to perform targeted imaging, and can be used in conjunction with a new CT technique – multicolor CT. Such innovations offer the promise of new applications and diagnoses that can be performed with C...

Abstract: Background: Bendamustine-loaded albumin nanoparticles were prepared using different concentrations of Bovine Serum Albumin (BSA) with the goal delivering medication to particular cancer cells. Materials and Procedures: The simple coacervation technique increasing BSA. characterized for process yield, particle size, surface morphology, drug loading capacity (%), size distribution (Poly...

PURPOSE The aim of the present study was preparation, physicochemical characterization and performance evaluation of gold nanoparticles (GNPs) in radiotherapy. Another objective was the investigation of anti-bacterial efficacy of gold nanoparticle against E. coli clinical strains. METHODS Gold nanoparticles prepared by controlled reduction of an aqueous HAuCl4 solution using Tri sodium citrat...

MRI Evaluation of a Peptide-Coated Nanoparticle as a Potential Therapy Against Preclinical Brain Metastatic Breast Cancer Amanda M Hamilton, Sallouha Aidoudi-Ahmed, Venkata R Kotamraju, Shweta Sharma, Paula J Foster, Kazuki N Sugahara, Erkki Ruoslahti, and Brian K Rutt Robarts Research Institute, London, Ontario, Canada, Sanford-Burnham Medical Research Institute, California, United States, Sta...

Rapid, sensitive and specific diagnostic assays play an indispensable role in determination of HIV infection stages and evaluation of efficacy of antiretroviral therapy. Recently, our laboratory developed a sensitive Europium nanoparticle-based microtiter-plate immunoassay capable of detecting target analytes at subpicogram per milliliter levels without the use of catalytic enzymes and signal a...