the aim of present study was to prepare gelatin nanoparticle for drug and gene delivery applications. these nanoparticles were prepared by two-step desolvation method. the body distribution of colloidal drug delivery systems was mainly influenced by two physicochemical properties namely particle size and surface characteristics. the influence of several factors on the fabrication process includ...

Nanotechnology is now applied to many industries, resulting in wide range of nanomaterial-containing products, such as electronic components, cosmetic, medicines, vehicles, and home appliances. Nanoparticles can be released throughout the life cycle of nanoproducts, including the manufacture, consumer use, and disposal, thereby involving workers, consumers, and the environment in potential expo...

The interactions between nanosized particles and living systems are commonly mediated by what adsorbs to the nanoparticle in the biological environment, its biomolecular corona, rather than the pristine surface. Here, we characterize the adhesion toward the cell membrane of nanoparticles of different material and size and study how this is modulated by the presence or absence of a corona on the...

Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study...

Purpose. The study reports evaluation of different purification processes for removing surplus surfactant and formulating stable nanoparticle dispersions. Methods. Nanoparticle formulations prepared from poly(D,L-lactide-co-glycolide) and polyvinyl alcohol (PVA) were purified by a diafiltration centrifugal device (DCD), using 300K and 100K molecular weight cut-off (MWCO) membranes and a tangent...

Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were conducted at various single intramuscular-decoquinate doses for 2, 4, 6, or 8 weeks prior to infection with P. berghei sporozoites. The liver stage effi...

Evaluation of simplifications for multi-compound nucleation provides assessments best practices and possible biases in model representation nanoparticle formation.