BACKGROUND Immunocompromised patients who develop sepsis while neutropenic are at high risk for morbidity and mortality; however, it is unknown if neutropenic sepsis is associated with distinct clinical and biological characteristics. METHODS We conducted a prospective cohort study of patients admitted to the medical intensive care unit of an academic medical center with severe sepsis. Patien...

OBJECTIVES To determine the incidence of neutropenic complications in patients receiving chemotherapy for advanced-stage non-Hodgkin's lymphoma (NHL), to predict which patients are at high risk for neutropenic complications and to develop an economic model for subsequent testing to assess the potential cost-effectiveness of prophylactic treatment with recombinant human granulocyte-colony stimul...

Neutropenic complications remain an important dose-limiting toxicity of cancer chemotherapy-associated with considerable morbidity, mortality, and cost. Risk of the initial neutropenic event is greatest during the first cycle. The purpose of this study was to better understand timing of neutropenic events in relation to delivered chemotherapy dose intensity and utilization of supportive care du...

backgrounds: neutropenia can be associated with life-threatening infections. gram negative and staphylococcal infections are the most common pathogens. the spectrum of bacterial isolates has changed considerably over the past four decades. the objective of the present study was to evaluate the pattern of bacterial and fungal infections in neutropenic pediatric patients.   methods: a non-randomi...

Neutropenic enterocolitis is a rare, life-threatening disease, characterized by fever and abdominal pain in the setting of neutropenia. It occurs most commonly in oncologic patients who are profoundly neutropenic as a result of cytotoxic chemotherapy. Neutropenic enterocolitis as a complication of medical therapy for rheumatoid arthritis (RA) has been rarely reported in literature. We describe ...

Background. Invasive fungal infections (IFI) are a significant source of morbidity and mortality in neutropenic patients. Risk based prophylaxis or pre-emptive therapy are debated clinical approaches. Since 2009, IPC at our tertiary care institution has collected the IFI rate per 1,000 neutropenic patient days. We examine IFI per neutropenic episode by patient characterictics and duration of ne...

Background: The use of a neutropenic diet after hematopoietic stem cell transplantation (HSCT) was instituted more than 30 years ago. This diet was targeted toward preventing from infection with organisms colonizing the gastrointestinal tract and the food-borne pathogens, which are the most important cause of illness and death in developing countries. Regarding this, the present study aimed to ...

Severe infections in neutropenic patient often progress rapidly leading to life-threatening organ dysfunction requiring admission to the Intensive Care Unit. Management strategies include early adequate appropriate empirical antimicrobial, early admission to ICU to avoid any delay in the diagnostic and therapeutic management of organ dysfunction. This review discusses the main clinical situatio...

The classic recommended antifungal agents for the treatment of invasive Candida infections were amphotericin B, a lipid formulation of amphotericin B and fluconazole in both neutropenic or nonneutropenic patients as either primary or alternative therapies. Voriconazole has been recommended when additional coverage for filamentous fungi is needed (e.g. neutropenic patients). More recently and ba...

BACKGROUND AND OBJECTIVES Staphylococcus aureus bacteremia (SAB) continues to be a major problem related to both community and nosocomially acquired infection. Nevertheless few data are presently available in literature about this infection in patients with hematologic malignancies. DESIGN AND METHODS The purpose of this retrospective study was to report further data on the clinical character...