Neutrophils are vital for host defense, but dysregulation in the pulmonary microvessels can cause acute lung injury and lead to respiratory distress syndrome. Understanding neutrophil trafficking is critical developing effective immunomodulatory therapies treat these pathologies. Neutrophil unique due diameter of capillaries (5μM) being smaller than neutrophils (8μM). This disparity results hav...

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, is encoded Tnfrsf9, belongs to the tumor necrosis superfamily and shown regulate neutrophi...

Teucrium polium, a medicinal plant that belongs to the family Labiatae is widely used in folk medicine as antidiabetic, antibactrial and anti-inflammatory agent. In this study, we evaluated the effect of Teucrium polium on the mouse polymorphonuclear neutrophils. The animals were divided into five groups including four test and one control group, which orally received 50 and 100 mg/kg of aqueou...