Acipimox is a nicotinic acid-derived antilipolytic drug devoid of major side effects, and has been used in a number of human trials. This work reports the effects of Acipimox on leptin production from isolated rat adipocytes, in comparison with nicotinic acid and insulin. For cells isolated from normal animals, all these three reagents stimulated leptin release to a similar extent. Acipimox and...

6-Hydroxynicotinic acid was demonstrated to be the first intermediate in the degradation of nicotinic acid by a clostridium. In the presence of pyruvate, other intermediates accumulated; two of these were identified, one as 1,4,5,6tetrahydro-6-oxonicotinic acid, and the other as a!-methyleneglutaric acid. The pathways for nicotinic acid degradation may be considered as involving successive oxid...

Gas-liquid chromatography was used to study the blood content of saturated and unsaturated fatty acids, under the influence of the functionally-associated vitamin-B complex, in 45 patients with coronary heart disease and essential hypertension. The vitamins were given daily in the following doses: thiamine diphosphate 50 mg, riboflavine 40 mg, calcium pantothenate 200 mg, nicotinic acid 200 mg ...

or quinolinic acid (or both). The modifying gene has no demonstrable effect on the utilization of exogenously supplied nicotinamide (K. Nakamura and C. S. Gowans, Genetics 51:931, 1965). Two observations strongly indicate that the modifying gene does not operate through a modification of the pathway of synthesis of niacin. First, the nicotinamide auxotrophs carrying the modifying gene grow norm...

The aim of this study was to investigate the effect coffee roasting process on both toxic and some beneficial antioxidant compounds, applying a systematic broad approach. Arabica Robusta green beans were roasted in lab-scale roaster for different times order achieve five degrees (from light dark) assess evolution acrylamide (AA), trigonelline, nicotinic acid caffeoylquinic acids contents (deter...

IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.

Hypertriglyceridemia is a rare cause of pancreatitis. In treatment pancreatic rest, lifestyle changes, medications (fibrates, n-3 polyunsaturated fatty acids, and nicotinic acid) are essential. Many experimental treatment modalities have been reported as insulin and heparin infusion and plasmapheresis. In this study we present the hypertriglyceridemia-induced pancreatitis treated with supportiv...

Bacteria able to grow with nicotinic acid as a sole source of carbon and nitrogen have been isolated by a number of investigators (l-5). Hughes et al. (6-10) found that Pseudomonas jlzwrescens initiates degradation of nicotinic acid by a hydroxylation to form 6-hydroxynicotinic acid and established that the responsible enzyme is located in a cell wall membrane fraction. An initial hydroxylation...

Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional surrogates of the nicotinic acetylcholine receptors when combined with transmembrane spans of the nicotinic receptor. These proteins assemble as a pentamer with identical ACh binding sites at the subunit interfaces and show ligand specificities resembling those of the nicotinic receptor for agonists and...