There have been few approaches to the oral inhibitor of nidation in this country. Among them was the study by Dr. Kawai (1962)' that GABOB (ƒÁ-Amino ƒÀ-hydroxybutylic acid), when orally administered, caused 3 out of 12 women the appearance of inadequate secretory phase in their uterine endo metrium. Investigations in the field of experimental zoology have shown that production of progesterone i...

The growth features of cells from endometriomas biopsied from patients who had been treated with Danazol or with hormones have not been studied in vitro. Danazol is a versatile drug and despite its recognised efficacy in controlling endometriosis, little is known about is cytotoxicity and mechanism of action. Culture of the biopsied endometriomas permitted qualitative cytotoxic assessments by w...

The mechanism(s) that regulates invasion of trophoblasts through the uterine epithelium during embryo implantation and nidation in hemochorial placental mammals is poorly understood. While limited trophoblast invasion is essential for the establishment of normal pregnancy, dysregulation of this process may contribute to the pathogenesis of choriocarcinoma, a highly invasive and lethal form of c...

Ova nidation took place in female mink treated with progesterone from the 2nd through the 30th day after mating. When treatments were stopped, the females began to resorb fetuses. Perhaps the treatments partially inhibited natural corpora production of hormones and, when treatments ceased, the corpora could not maintain all the embryos. A lack of progesterone may also have prevented proper brea...

C'est une patiente âgée de 37ans, primipare, ayant comme antécédent une stérilité secondaire de 17ans, admise aux urgences pour des métrorragies associées à des douleurs pelvienne sur une aménorrhée de 2mois. L'examen trouve une patiente tachycarde, TA à 90/50mmhg, un abdomen légèrement distendu, avec un saignement provenant de l'endocol. Echographie pelvienne objective un utérus de taille norm...

Justicia insularis T. Anders (Acanthaceae) is a medicinal plant whose leaves and those of three other plants are mixed for the preparation of a concoction used to improve fertility and to reduce labour pains in women of the Western Region of Cameroon. Previous studies have demonstrated the inducing potential on ovarian folliculogenesis and steroidogenesis of the aqueous extract of the leaf mixt...

The mode of zona pellucida denudation and blastocyst proliferation and attachment was investigated in Wistar rats during day 5 of pregnancy and in ovariectomized pregnant animals given 5-0 mg progesterone daily until the 10th day, when 0-2 mug oestradiol was injected together with progesterone. During day 5 of pregnancy, when only 5 empty zonae were detected from 32 animals, zona denudation occ...