نتایج جستجو برای: niddm
تعداد نتایج: 1209 فیلتر نتایج به سال:
Objective: To evaluate the vulnerability of gastric mucosa to ulceration in non-insulin-dependent diabetes mellitus (NIDDM) rats vis-à-vis the protective effects of the methanolic extract of Pterocarpus marsupium heartwood (PMS, an antidiabetic herbal plant). Material and Methods: NIDDM was produced in 5-day-old rat pups by administering streptozotocin (70 mg/kg, i.p). The animals showing blood...
We examined the effect of physiological hyperinsulinemia on insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation and phosphatidylinositol (PI) 3-kinase activity in skeletal muscle from six lean-to-moderately obese NIDDM patients and six healthy subjects. A rise in serum insulin levels from approximately 60 to approximately 650 pmol/l increased IRS-1 tyrosine phosphorylation sixfold ove...
BACKGROUND & AIMS We investigated whether risk for non-insulin-dependent diabetes mellitus (NIDDM) and metabolic syndrome are affected by celiac disease. We examined the prevalence of NIDDM and metabolic syndrome among adults with celiac disease, compared with matched controls. METHODS We assessed medical records of 840 patients with biopsy-proven celiac disease for diagnoses of NIDDM, hypert...
OBJECTIVE To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM. RESEARCH DESIGN AND METHODS We describe the methodology and sample of the Finland-United States Investigation of NIDDM Genetics (FUSION) study. The whole genome search approach is being applied in studies of several different ethnic groups to locate susceptibility g...
گرفتگی عروق کرونر قلب ( cad ) یکی از علل مرگ و میر در بیماران دیابتی غیروابسته به انسولین ( niddm ) می باشد. یکی از عوامل خطرزا در ابتلا به cad ، غیرطبیعی بودن لیپیدها است. با توجه به شیوع بالای niddm و cad در مردم کشورمان، در این مطالعه، سطح لیپیدها و لیپوپروتئین ها در سرم خون 2 گروه از بیماران (گروه + /niddm + cad و گروه - /niddm + cad ) اندازه گیری و با یکدیگر مقایسه گردید. هر کدام از گروه ه...
The human insulin receptor has two isoforms derived from alternative splicing of exon 11 of the insulin receptor gene. The type B (containing exon 11, or exon 11+) isoform binds insulin with twofold lower affinity than the type A (lacking exon 11, or exon 11-) isoform. In efforts to resolve the controversy over whether altered splicing is involved in the development of insulin resistance and no...
Non-insulin-dependent diabetes mellitus (NIDDM) is one of the most prevalent chronic conditions worldwide. Despite an important role of genetic factors, NIDDM can be viewed as a largely preventable disease. In this article, the current epidemiologic evidence on potentially modifiable determinants of NIDDM is reviewed, including obesity, body fat distribution, physical activity, and dietary fact...
Non-insulin dependent diabetes mellitus (NIDDM) is most commonly current metabolic disorder as it affects more than 385 million and it is expected to reach about 590 million by 2035 worldwide [1], so that NIDDM has huge economic burden and adverse medical effects as there is a risk of fracture due to bone fragility in spite many researches confirm normal or even higher bone mineral density (BMD...
Changes in insulin secretory responses by diet restriction were analyzed in non-insulin-dependent non-obese diabetic subjects (NIDDM-NO) as well as in healthy volunteers by determining 24-hr urinary C-peptide immunoreactivity (24-hr UCPR). Insulin sensitivity for glucose utilization was measured by using cyclic somatostatin. Overnight fasting plasma glucose concentrations decreased in NIDDM-NO;...
Because the activity of mitochondrial glycerol phosphate dehydrogenase (mGPD) in the pancreatic 3-cell is normally among the highest of the body, but is low in the pancreatic islets of numerous rodent models of NIDDM and is reported to be low in the islets of the few humans studied with NIDDM (1,2), it has been questioned whether mGPD might be a diabetes candidate gene. Linkage studies have fai...
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