نتایج جستجو برای: nitricoxide
تعداد نتایج: 39 فیلتر نتایج به سال:
BACKGROUND Myeloid differentiation factor 88 (MyD88) is an adaptor molecule critical for host innate immunity. Studies have shown that signaling via MyD88 contributes to cytokine storm, cardiac dysfunction, and high mortality during endotoxin shock.However, the specific contribution of MyD88 signaling of immune and cardiac origins to endotoxin shock remains unknown. METHODS Tissue-specific My...
Stimulation of freshly isolated rat hepatocytes with lysophosphatidic acid (LPA) resulted in LPA1 receptor-mediated and nitricoxide-dependent up-regulation of the immediate early genes iNOS (inducible nitric-oxide synthase (NOS)) and mPGES-1 (microsomal prostaglandin E synthase-1). Because LPA is a ligand for both cell surface and intracellular receptor sites and a potent endothelial NOS (eNOS)...
Reactive oxygen/nitrogen species suppress myocardial oxygen consumption. In this study, we determined that endogenous hydrogen peroxide through dismutation of superoxide enhances postischemic myocardial blood perfusion and oxygen consumption. Electron paramagnetic resonance oximetry was applied to monitor in vivo tissue Po2 in mouse heart subjected to regional ischemia reperfusion. Heart rate, ...
Interactions and possible cross talk between inducible nitricoxide synthase (iNOS), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9), were studied in rat aortic vascular smooth muscle cells stimulated with bacterial lipopolysaccharide (LPS), interferon-gamma (IFN-gamma), and phorbol 12-myristate13-acetate (PMA). The expression and activity of iNOS, COX-2, and MMP-9 were character...
introduction: the role of ovarian hormones and nitric oxide (no) in learning and memory and their interaction has been widely investigated. the present study carried out to evaluate different effect of l-name on spatial learning and memory of ovariectomized (ovx) and sham operated rats. methods: 32 rats were divided into 4 groups: 1) sham 2) ovx 3) sham-ln and 4) ovx-ln. the animals of groups 3...
Background and purpose: This study presents the effects of nitricoxide synthase inhibitor (L-NAME) on WIN55, 212-2 induced state-dependent memory of passive avoidance task, which were examined in mice. Materials and methods: Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. Also, two stainless-steel...
The cyclopentenone prostaglandin and PPAR agonist 15-deoxy-prostaglandin J2 (15d-PGJ2) displays anti-inflammatory effects in several experimental models. Direct modification of protein thiols is arising as an important mechanism of cyclopentenone prostaglandin action. However, little is known about the extent or specificity of this process. Mesangial cells (MC) play a key role in glomerulonephr...
زمینه و هدف: نیتریک اکساید(no=nitric oxide)، مولکولی کوچک و لیپوفیل با نقشهای متعدد و گسترده در سیستم های بیولوژیک بدن می باشد که فعالیت ضد توموری و ضد میکروبی از خود نشان می دهد. تحریک ماکروفاژها توسط میکروارگانیسم های گوناگون منجر به تولید مقدار زیادی no می شود که خاصیت سمی داشته و نهایتاً موجب مرگ میکروارگانیسم می شود. مکانیسم های وابسته به no نقش کلیدی در دفاع میزبان علیه عفونت های قارچی ایف...
BACKGROUND Alpha lipoic acid is a potent antioxidant that plays numerous roles in human health. This study examined the effect of ALA on rat sciatic nerve ischemia reperfusion damage. AIMS Protective effect of alpha lipoic acid (ALA) on sciatic nerve following ischemia-reperfusion in rats was investigated by using light microscopy and biochemical methods. Provided that the protective effect o...
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