background and aims. many oral squamous cell carcinomas develop from potentially malignant disorders (pmds) which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. this study evaluated the quantitative expression of egfr in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with ...

Introduction: Although recent studies show the association of eosinophils with different tumors including oral malignancies, the role of eosinophils in premalignant conditions of the oral cavity is not known precisely. Therefore, this study aimed to determine the number of eosinophils in premalignant and malignant conditions of the oral cavity and its role in progression to malignancy. Materia...

many types of cancers develop in the oral and maxillofacial region. squamous cell carcinoma is the most common cancer and constitutes over 90 percent of these tumors. malignant transformation is a genetic process, which later makes a phenotyping change at the cellular level. some cancers such as oral squamous cell carcinomas (osccs) develop from pre-malignant lesions and conditions. despite adv...

Many types of cancers develop in the oral and maxillofacial region. Squamous cell carcinoma is the most common cancer and constitutes over 90 percent of these tumors. Malignant transformation is a genetic process, which later makes a phenotyping change at the cellular level. Some cancers such as oral squamous cell carcinomas (OSCCs) develop from pre-malignant lesions and conditions. Despite adv...

amelanotic melanoma is a variant of malignant melanoma comprising 2% to 8% of all malignant melanomas. the amelanotic presentation of melanoma in the oral cavity is extremely rare and has been reported only occasionally in the literature. moreover, the lack of melanin makes these tumors difficult to diagnose than that of pigmented lesions and the prognosis tends to be poorer. herein, we report ...

oral submucous fibrosis (osmf) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut. since its first description in the 1950s, numerous epidemiological, biochemical, histological, and genetic studies have been reported. while most studies point out to the cause and effect of areca nut, co-additive factors are also implicated in the progression...

oral lichen planus (olp) is a chronic inflammatory disease of the oral mucosa which is considered by the world health organization (who) as a premalignant condition. one step in malignant development is so called epithelial mesenchymal transition (emt), a process whereby epithelial cells acquire mesenchymal characteristics. a factor known to induce emt is the transforming growth factor-β (tgf-β...