parkinson's disease (pd) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring alzheimer's disease (ad). currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of pd. out of several factors contributing to pd prognosis, the role of p38 mapks (mitog...

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...

Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis a pathophysiological of cardiac aging. Mangiferin well-known C-glucoside xanthone mango leaves with lots beneficial properties. In this study, rat model was induced by injected 150 mg/kg/d D-galactose for 8 weeks. The age-related decline estimated detecting relative weight heart, serum levels injury indicators and...

Neuroinflammation contributes to delayed (secondary) neurodegeneration following traumatic brain injury (TBI). Tumor necrosis factor receptor-associated 6 (TRAF6) signaling may promote post-TBI neuroinflammation, thereby exacerbating secondary injury. This study investigated the pathogenic functions of TRAF6 TBI in vivo and vitro . A rat model was established by air pressure contusion while lip...

The synergistic effect of dual inhibition serine/threonine protein kinases that are involved in the same signalling pathway diseases can exert superior biological benefits for treatment these diseases. In present work, a new series (imidazol-5-yl)pyrimidine was designed and synthesized as inhibitors BRAFV600E p38? which considered key regulators mitogen-activated kinase (MAPK) pathway. target c...

The molecular clock component Brain and Muscle Arnt-Like protein-1 (BMAL-1) affects various biologic processes, including cell survival, in numerous types. We previously demonstrated that BMAL1 positively regulates proliferation Vascular Smooth Cells (VSMCs). However, its role VSMC inflammation remains unelucidated. Because doxorubicin causes phlebitis associated with vascular inflammation, the...

objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...

Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. Materials and Methods:We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. Results:FA increased cell viability, prevented membrane damage (LDH r...