OBJECTIVES The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG400 as plasticizer. MATERIALS AND METHODS Polyethylene glycol (PEG400) in concentrations of 1, 3 or 5% w/w with respect to Eudragit RL was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

In this research, the effects of oxygen injection during the induration process were studied in order to improve the quality specifications and increase the rate of production of the iron oxide pellets. Several experiments were carried out in palletizing pilot plant in different conditions of oxygen injection. The results suggested that if only the extra oxygen was injected into the furnace in ...

The aim of this work was to study the effect of several process parameters used during pellets coating in two wurster fluid beds of different scales on: a) the uniformity of pellets coating, and b) the presence of an initial burst in the release profile caused by the existence of a significant fraction of pellets having a very thin film coating. The pellets used in this work presented high insu...

Studies of fecal pellet flux show that a large percentage of pellets produced in the upper ocean is degraded within the surface waters. It is therefore important to investigate these degradation mechanisms to understand the role of fecal pellets in the oceanic carbon cycle. Degradation of pellets is mainly thought to be caused by coprophagy (ingestion of fecal pellets) by copepods, and especial...

OBJECTIVES This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. MATERIALS AND METHODS The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liquid ...

A pH sensitive multi-particulate system intended to approximate the chronobiology of angina pectoris is proposed for colonic targeting. The system comprising of Eudragit S-100 coated pellets was designed for chronotherapeutic delivery of diltiazem hydrochloride. The drug loaded core pellets were produced by aqueous extrusion spheronization technique using microcrystalline cellulose as a spheron...

Fresh urine pellets from human immunodeficiency virus type 1 (HIV-1)-seropositive individuals were examined for the presence of the HIV-1 genomic sequence and gene products. By using the polymerase chain reaction technique, HIV-1 DNA proviral sequences were detected in 53 of 80 (66.25%) fresh urine pellets from HIV-1-seropositive individuals, while urine pellets from all 24 healthy heterosexual...

In this study different sized sustained-release coated pellets (6, 2.5 and 1 mm in diameter) were investigated using terahertz pulsed imaging (TPI). Ten pellets from each batch of metoprolol succinate layered sugar starter cores coated with a 75:25 (w/w) polymer blend of Kollicoat SR and Kollicoat IR (approximate coating thickness of 60 μm, according to the weight gain) were mapped individually...

laser fusion simulations are carried out for dt and d- he pellets by using a hydrodynamic code including heating from all charged reaction products and neutrons. it is shown that the inclusion of the side reactions and heating from all reaction products in the fuel pellets have an appreciable effect on the plasma temperature, the icf drive energy requirement, fusion gain and the ignition condit...