Background: Sleep disorder, frequently observed among perimenopausal women, decreases quality of life. Melatonin is reported to ameliorate circadian imbalances and thus can be employed as a treatment for sleep disorder patients. We attempted clarify whether how melatonin affects disorders. Methods: Study patients consisted 120 women divided into 3 groups: (i) without (n = 60); (ii) those with b...

The aim of the experiment was to compare 3 genetic groups, slaughtered at similar weights, to examine their productive and carcass traits and economic value. Three lines of the Pannon Breeding Programme, selected for different criteria, were examined in the experiment. Pannon Ka (PKa, maternal line) does were inseminated with semen of PKa, Pannon White (PWhite) or Pannon Large (PLarge, terminal...

neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...

Zusammenfassung Eine zentrale Voraussetzung der Unterrichtsforschung besteht darin, Unterrichtsmerkmale angemessen zu erfassen. Die Einschätzung des (gefilmten) Unterrichts durch geschulte Rater*innen gilt dabei als Königsweg, ist jedoch mit einem hohen organisatorischen und zeitlichen Aufwand verbunden. Im Rahmen dieses Artikels wird ein neu entwickeltes Erhebungsinstrument für das Unterrichts...

Neuritogenesis is a process through which neurons generate their widespread axon and dendrites. The microtubule cytoskeleton plays crucial roles throughout neuritogenesis. Our previous study indicated that the amount of type II protein kinase A (PKA) on microtubules significantly increased upon neuronal differentiation and neuritogenesis. While the overall pool of PKA has been shown to particip...

In this study, the direct determination of cefixime as an anti-bacterial agent, in pharmaceutical formulations, urine and human blood plasma was conducted based on spectrophotometric measurements using parallel factor analysis (PARAFAC) and partial least squares (PLS). The calibration set was composed of fourteen solutions in the range of 0.50- 9.00 µg mL-1. PLS models were calculated at each p...

We identified a unique type II cAMP-dependent protein kinase regulatory subunit (PKA-RII) gene in Drosophila melanogaster and a severely hypomorphic if not null mutation, pka-RII(EP(2)2162). Extracts from pka- RII(EP(2)2162) flies selectively lack RII-specific autophosphorylation activity and show significantly reduced cAMP binding activity, attributable to the loss of functional PKA-RII. pka-R...

A voltammetric method has been developed for the determination of acid dissociation constant (pKa) (RfSO2)2CHR (Rf = perfluoroalkyl), which is a strongly acidic molecule that serves as an catalyst. In acetonitrile solution containing small quantity acid, reduction peak potential quinone caused by shifted to more positive side accompanied increase in acidity acid. This relationship was good agre...

Cells in the pedunculopontine tegmentum (PPT) play a key role in the generation of rapid eye movement (REM) sleep, but its intracellular signaling mechanisms remain unknown. In the current studies, the role of PPT intracellular protein kinase A (PKA) in the regulation of REM sleep was evaluated by comparing PKA subunit [catalytic (PKA(C alpha)) and regulatory (PKA(RI), PKA(RII alpha), and PKA(R...