ANDERSON, H. L., N. J. BENEVENGA, AND A. E. HARPER. Associations among food and protein intake, serine dehydratase, and plasma amino acids. Am. J. Physiol. 214(5): 1008-1013. 1968.Relationships among liver serine-threonine dehydratase activity, plasma amino acid concentrations, and food and protein intake were studied in growing rats undergoing adaptation to high-protein diets. Serine-threonine...

background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

The Membrane Proteins (MPs) on the cell membrane, is an ideal target for drug delivery owing to their distinct location membrane and intracellular structure. To locate multitude of MPs with better accuracy, we implemented SVM Benchmark MP Database, MemLoci Dataset. A total 3000 proteins are selected 1000 plasma proteins, internal organelle proteins. amino acid sequence converted into Pseudo Ami...

Glucose intolerance, hyperinsulinemia, peripheral insulin resistance and hyperglucagonemia are common in patients with advanced liver disease. These abnormalities in the plasma levels of the pancreatic hormones, insulin and glucagon have been thought to be responsible, at least in part, for the abnormal plasma ratio of branched-chain amino acids to aromatic amino acids. To evaluate this issue, ...

We examined whether high flux membranes (HF) may induce a greater loss of amino acids compared to low flux membranes (LF). Ten hemodialysis patients participated in this study. Pre- and post-hemodialysis plasma amino acid profiles were measured by reverse-phase high pressure liquid chromatography for both HF and LF. We measured the dialysate amino acid losses during hemodialysis. The reduction ...