نتایج جستجو برای: pldh

تعداد نتایج: 124  

2015
Ross Boyce Raquel Reyes Moses Ntaro Edgar Mulogo Michael Matte Yap Boum Mark J. Siedner

The detection of severe malaria in resource-constrained settings is often difficult because of requirements for laboratory infrastructure and/or clinical expertise. The aim of this study, therefore, was to explore the utility of a multiple antigen (HRP-2/pLDH) rapid diagnostic test (RDT) as a low-cost, surrogate marker of patients at high risk for complications of severe malaria. We reviewed pr...

2011
Ilse C. E. Hendriksen George Mtove Alínia José Pedro Ermelinda Gomes Kamolrat Silamut Sue J. Lee Abraham Mwambuli Samwel Gesase Hugh Reyburn Nicholas P. J. Day Nicholas J. White Lorenz von Seidlein Arjen M. Dondorp

BACKGROUND Rapid diagnostic tests (RDTs) now play an important role in the diagnosis of falciparum malaria in many countries where the disease is endemic. Although these tests have been extensively evaluated in uncomplicated falciparum malaria, reliable data on their performance for diagnosing potentially lethal severe malaria is lacking. METHODS We compared a Plasmodium falciparum histidine-...

2013
Philippe Gillet Dieudonné Mumba Ngoyi Albert Lukuka Viktor Kande Benjamin Atua Johan van Griensven Jean-Jacques Muyembe Jan Jacobs Veerle Lejon

BACKGROUND In endemic settings, diagnosis of malaria increasingly relies on the use of rapid diagnostic tests (RDTs). False positivity of such RDTs is poorly documented, although it is especially relevant in those infections that resemble malaria, such as human African trypanosomiasis (HAT). We therefore examined specificity of malaria RDT products among patients infected with Trypanosoma bruce...

2011
Julia Penna-Coutinho Wilian Augusto Cortopassi Aline Alves Oliveira Tanos Celmar Costa França Antoniana Ursine Krettli

The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90% identity to PfLDH, it would be desirable to have new anti-pLDH drugs, particularly ones that are effe...

Journal: :Molecules 2017
Malose J Mphahlele Mmakwena M Mmonwa Yee Siew Choong

A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5-diaryl-1H-indol-7-yl)ethanones, followed by trifluoroacetylation of the incipient N-(2,5-diaryl-1H-indol-7-yl)-acetamides with trifluoroacetic anh...

Journal: :Mathematics 2023

Deep hashing has received a great deal of attraction in large-scale data analysis, due to its high efficiency and effectiveness. The performance deep models heavily relies on label information, which is very expensive obtain. In this work, novel end-to-end model based pseudo-labels for without labels proposed. proposed consists two major stages, where the first stage aims obtain features extrac...

2016
Christine F. Markwalter Keersten M. Ricks Anna L. Bitting Lwiindi Mudenda David W. Wright

We have developed a rapid magnetic microparticle-based detection strategy for malarial biomarkers Plasmodium lactate dehydrogenase (pLDH) and Plasmodium falciparum histidine-rich protein II (PfHRPII). In this assay, magnetic particles functionalized with antibodies specific for pLDH and PfHRPII as well as detection antibodies with distinct enzymes for each biomarker are added to parasitized lys...

Journal: :The American journal of tropical medicine and hygiene 2008
Hanitra Rakotonirina Céline Barnadas Rogelin Raherijafy Hery Andrianantenaina Arsène Ratsimbasoa Laurence Randrianasolo Martial Jahevitra Valérie Andriantsoanirina Didier Ménard

The main purpose of this study was to assess the accuracy of various techniques available for diagnosis of malaria. Blood samples were collected from 313 patients with clinical suspicion of uncomplicated malaria in 2 primary health centers in Madagascar. The presence of Plasmodium parasites was assessed by conventional microscopy, 2 rapid diagnostic tests (one HRP2-based test, PALUTOP(+4), and ...

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