The plus-maze was derived from the early work of Montgomery. He observed that rats tended to avoid the open arms of a maze, preferring the enclosed ones. Handley, Mithani and File et al. performed the first studies on the plus-maze design we use today, and in 1987 Lister published a design for use with mice. Time spent on, and entries into, the open arms are an index of anxiety; the lower these...

I read the recently published article in Vol 6 (3) of Basic and Clinical Neuroscience entitled “Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus- Maze” by Komaki et al. (2015). In this valuable article, the authors uncovered the effects of AM251 as a CB1 receptor antagonist on anxiety-like behaviors of rats using elevated plus-maze

A single 5 min exposure to the elevated plus-maze test of anxiety renders animals insensitive to the anxiolytic effects of the benzodiazepines in this test. The purpose of the present experiments was to explore whether this phenomenon resulted from a change in the functional state of benzodiazepine receptors in the dorsal raphe nucleus. The benzodiazepine receptor agonist midazolam (0.5, 1, and...

conclusions acute and chronic administration of ellagic acid had anxiolytic property. also, the most effective dose of ellagic acid was 30 mg/kg. pretreatment with flumazenil reversed the beneficial effect of ellagic acid and diazepam on anxiety. it is likely that the anxiolytic effect of ellagic acid is largely mediated by activation of gabaa receptor. results acute and chronic application of ...

Systematic observations of the defensive behavior of wild rodents have greatly informed the experimental study of anxiety and its neural substrates in laboratory animals. However, as the former work has been almost exclusively carried out in rats, few data are available concerning the reactivity of wild mice to standardized tests of anxiety-related behavior. In the present experiments, we emplo...

HIGHLIGHTS: Tumor progression and anxiety depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of through forced swimming behavior tests, elevated plus maze, open field marble-burying test.

Tamarindus indica (Fabaceae) have been using in traditional medicine to cure various diseases, including mental stress and anxiousness. The current study was aimed evaluate phytochemical analysis anxiolytic activity of flower extracts (n-Hexane, Ethyl acetate, Chloroform methanol) different animal models such as elevated plus-maze, mirror chamber, light/dark, hole board tests. had showed presen...