نتایج جستجو برای: point mutation
تعداد نتایج: 796715 فیلتر نتایج به سال:
conclusions in the present study, the frequency of clarithromycin resistance was lower than the other studies conducted in iran. resistance frequency in samples isolated from gastric ulcer was higher than other gastric disorders. women and patients aged more than 60 years old showed the most resistance frequency in this study. all resistant strains had the a2143g genotype. results of the 89 h. ...
Background and Aims: lamivudine is amongst the antiviral for drug chronic hepatitis B treatment. During therapy with lamivudine, variants may emerge with YMDD mutation in the reverse transcriptase (RT) region of polymerase gene. This mutation might have a role in drug resistant for HBV. Materials and Methods: HBV DNA extraction from serum sample of 88 patients, were subjected to nested PCR for ...
introduction: a number of maternally inherited mitochondrial diseases with distinct clinical phenotypes have been associated with point mutations in mtdna, all of which result in neurologic or neuromuscular disorders. several studies showed that mutations in the trna genes of mtdna could cause mitochondrial disease due to the decreased synthesis of mitochondrial dna coded proteins. materials an...
conclusions we concluded from the results that the frequency of emb-resistant m. tuberculosis cases in iran is lower than that of many other regions. the pcr-sscp technique can separate resistant isolates from sensitive isolates. the sequencing results of this study showed mutation in codons 309 and 299 of the embb gene. in none of the resistant isolates, mutation was observed in codon 306. fur...
lots of viruses, in particular rna viruses, have high mutation rates and relatively short generation times. particle stability during infection in nature or in laboratory triggers the evolutionary event toward different mechanisms such as genome segmentation, point mutation and recombination. the frequency of mutant genomes increase and modify the previous distribution, which, consequently, l...
Background: Behcet’s disease (BD) is a multisystemic inflammatory disease with unknown origin characterized by recurrent oral aphtous ulcers, genital, ocular and skin lesions. A single point mutation 1691G to A in the factor V gene increases the risk of venous thrombosis. This study designed to determine factor V Leiden mutation in Behcet’s disease, and to find out it's relationship with the cl...
The clustering problem under the criterion of minimum sum of squares is a non-convex and non-linear program, which possesses many locally optimal values, resulting that its solution often being stuck at locally optimal values and therefore cannot converge to global optima solution. In this paper, we introduce several new variation operators for the proposed hybrid genetic algorithm for the cl...
introduction: haemophilia a is the most common inherited x-linked recessive bleeding disorder. the severity of the resultant bleeding diathesis depends on the fviii levels associated with the mutation. analysis of carrier state can be made indirectly by dna linkage analysis or directly by identifying the mutation that leads to the disease. the aim of this study was to identification of the caus...
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