UNLABELLED Fluorine-18-labeled 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)-8-[-3-fluoropropyl) nortropane (FPCT) has been synthesized as a new dopamine transporter imaging agent. METHODS Fluorine-18 was introduced into 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)-8-[-3-fluoropropyl) nortropane by preparation of 1-[18F]fluoro-3-iodopropane followed by alkylation of 2 beta-carbomethoxy-3 beta-(4...

The thermal cis-to-trans isomerisation process has been studied for a series of para-, ortho- and polyhydroxy-substituted azobenzenes in different solvents. The kinetics of the thermal back reaction for the p-hydroxy-substituted azobenzenes depend strongly on the nature of the solvent used, with relaxation times ranging from 200-300 milliseconds in ethanol to half an hour in toluene. Otherwise,...

A heated oxide covered copper electrode (HOCE) was facilely fabricated for the first time, providing a highly enhanced electrocatalytic oxidation, and cost effective and sensitive determination for polyhydroxy compounds such as glucose and shikimic acid.

In the presence of Ni-catalyst and triethylborane, N,O-acetals prepared from glycolaldehyde and glyceraldehyde with primary amines in situ underwent homoallylation with conjugated dienes to provide 2-amino-5-hexenols in high regio- and stereoselectivity. Under similar reaction conditions, N,O-acetals from carbohydrates with primary amines provided the corresponding polyhydroxy-bishomoallylamine...

The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.

Natural products derived from medicinal and edible plants, such as polysaccharides, polyphenols, flavonoids, alkaloids, are a valuable source of potential drug candidates have attracted interest for their rich structural motifs diverse physiological activities. Therefore, the discovery new natural with unique structures bioactivity esculent resources has emerged promising approach...

In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO(2)) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino...