Introduction: As a result of aging process, oral mucosa becomes susceptible to oral diseases. Having knowledge about prevalence and distribution of geriatric oral diseases is essential for prevention and treatment planning. This study aimed to evaluate the prevalence of geriatric patients’ oral biopsies in specimens obtained in medical centers of Zahedan University of Medical Sciences. Methods:...

In many tumors, the switch from precancerous lesions to malignancy critically relies on expression of the matrix-metalloprotease MMP-9, which is predominantly provided by infiltrating inflammatory cells. Our study defines a novel molecular cascade, how human neoplastic cells instruct tumor-associated myeloid cells to produce MMP-9. In biopsies of human papillomavirus-associated precancerous cer...

Objectives: To determine associations, if any, of bacterial vaginosis with cervical pre-neoplastic lesions and evaluate any effects of sub-categorization of smears with bacterial vaginosis. Methods: All cervico-vaginal smears reported as positive for bacterial vaginosis over a five-year period were reviewed and sub-categorized into ‘type I (dysbacteriosis)’ and ‘type II (pure Gardenerella infec...

Introduction: Different oral lesions have clinical characteristics which in some cases are similar. Therefore, in these cases histopathological examination for correct diagnosis is necessary. The aim of this study was to evaluate the compatibility rate of clinical and histopathological diagnosis of oral lesions in Zahedan School of dentistry. Methods: In this retrospective study, determination ...

Method: Two hundred and nine patients who were diagnosed with precancerous lesions and referred to the dermatology department of Imam Reza hospital from 1997 to 2007 were studied. Study parameters included participants’ age, sex and occupation, type of precancerous skin lesion, clinicopathological type of the lesion and location. The data was collected from the patients’ records in the dermatol...

A 73-year-old man with short segmental Barrett's esophagus underwent esophagoscopy, and a slightly depressed, discolored lesion was found on the anterior wall of the lower esophagus. Under a provisional diagnosis of differentiated adenocarcinoma without local lymph node metastasis, endoscopic submucosal dissection (ESD) was carried out. En bloc resection with tumor-free lateral/basal margins wa...