Berry, C. L. (1971). Archives of Disease in Childhood, 46, 709. Cyclophosphamide therapy in prepubertal rats and subsequent reproductive performance. In an experimental system using rats, prepubertal treatment with cyclophosphamide was associated with slightly reduced fertility of the adult female. No malformations were noted in the offspring, and there was no change in the size of the rat pups...

Following an acute stressor, pre-adolescent rats exhibit a protracted hormonal response compared to adults, while after repeated exposure to the same stressor (i.e., homotypic stress) prepubertal males fail to habituate like adults. Though the neurobehavioral implications of these changes are unknown, studying pubertal shifts in stress reactivity may help elucidate the mechanisms that underlie ...

Monoamines and dehydroepiandrosterone (DHEA) levels were measured in a genetic animal model for childhood depression in four subcortical structures: nucleus accumbens (Nac), ventral tegmental area (VTA), amygdala and hypothalamus. The "depressive-like" strain was the Flinders Sensitive Line (FSL), compared to their controls, Sprague-Dawley (SD) rats. Prepubertal FSL rats showed abnormal levels ...

We studied the contractile activity and glucose metabolism, in terms of production of 14CO2 from [14C] glucose, in isolated uteri of immature rats. Immaturity was due to age or exposure to a restricted diet. The contractile activity in both prepubertal groups persisted for a period of 60 minutes and fell when indomethacin was added to the KRB medium. The production of 14CO2 was greater than for...

Chemically, soy contains a group of phytoestrogens called isoflavones, predominantly genistein and daidzein. The aim of the present study was to determine the effects of post weaning consumption of dietary soy isoflavones on prepubertal and postpubertal serum levels of some reproductive hormones of male Wistar rats. The study involved investigating the effects of different doses of isoflavones ...

PURPOSE Previous studies have shown that the removal of one testis leads to a compensatory mechanism in the contralateral one, but this was species and age dependent. The aim of this study was to check whether this compensation would still occur after the combination of a unilateral orchiectomy and gonadotoxic treatment, since this resembles the clinical situation of patients who have to underg...

The purpose of this study was to investigate the impact of prepubertal ovariectomy and postpubertal administration of testosterone on inducibility of rat hepatic CYP2B1 and CYP2B2 by phenobarbital. Intact adult male and female Sprague-Dawley rats were injected ip with sodium phenobarbital (10 mg/kg) or saline (control) once daily on days 129-135 of age and sacrificed one day after the last dose...

Physical activity has a vital role in regulating and improving bone strength. Responsiveness of bone mass to exercise is age dependent with the prepubertal period suggested to be the most effective stage for interventions. There is a paucity of data on the effects of exercise on bone architecture and body composition when studied within the prepubertal period. We examined the effect of two form...

Introduction: Perepubertal varicocele can result in hypotrophy of testes, sperm damage and decrease the function of leydig cells in future. pathophysiology of varicocele is unclear. Increased reactive oxygen species (ROS) is a major theory. There are many controversies in treatment of pediatric varicocele. Flaxseed (FS) is the richest source of lignans with antioxidant properties. The aim of...

background: previous researches about the effects of epididymal obstruction on the testes are contradictory, and the mechanism harmful effect of male duct system obstruction on seminiferous tubules still remains unclear. objective: the aim of this study was to investigate the effects of epididymal obstruction in prepubertal rats on the testis. materials and methods: 15 days of age, the young ra...