thyroid gland dysfunction is associated with disorders of female reproductive functions. the aim of this study was to examine the effects of hyperthyroidism on ovulation rate and peripheral sex steroid levels in prepubertal and adult rats. two groups of female rats aging 30 days (prepubertal rats) and 60 days (adult rats) were made hyperthyroid by oral administration of levothyroxine daily. in ...

Pendrin (PDS) and sodium/iodide symporter (NIS) are transmembrane proteins that are located in numerous tissue types, particularly thyroid follicular epithelial cells, where they are entrusted with the regulation of iodine molecules. In the present study, we aimed to clarify changes in PDS and NIS protein expression, in the testicular tissue of prepubertal and <span la...

This study investigated the effects of 30-day exposure to tobacco smoke (TS), smokeless tobacco (ST), and nicotine on reproductive parameters and oxidative biomarkers in prepubertal and adult male rats. Sperm motility was reduced by 77.5 and 89.0% in TS and ST exposed prepubertal rats and 71.1 and 86.4% in adult rats, respectively. Sperm count was also reduced by 64.7 and 89.9% in prepubertal r...

One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different "depressed" lines were studied: the...

Thyroid gland dysfunction is associated with disorders of female reproductive functions. The aim of this study was to examine the effects of hyperthyroidism on ovulation rate and peripheral sex steroid levels in prepubertal and adult rats. Two groups of female rats aging 30 days (prepubertal rats) and 60 days (adult rats) were made hyperthyroid by oral administration of levothyroxine daily...

Prepubertal (14 days old) and mature (10 to 12 months old) male rats were hemicastrated and killed at selected intervals during a 12-week period to compare the effect of age on acute and chronic pituitary and testicular responses to hemicastration. Testis weight was increased (P less than 0.05) in hemicastrated (HC) prepubertal rats but not in mature rats compared with intact controls. After su...

Basal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of "Brain-Derived Neurotrophic Factor (BDNF)" were also determined in two regions in the hippocampus, compared with Wistar strain controls. In the second phase, we examined the responsiveness of prepubertal WKY...

This experiment was designed to study the effects of caffeine on histomorphology testes prepubertal male Wistar rats. Prepubertal rats (25-28 days old), weighing between 50-60 g were randomly divided into three treatment groups (B, C and D) control (A) ten each. Group A received distilled water while Groups B, C, D respectively given daily dose 50 mg/kg, 100 200 mg/kg dissolved in for 14 by gav...

background: prepubertal varicocele has the most devastating effects on the testes. oxidative stress is the major cause leading to infertility in varicocele. the antioxidant properties of flaxseed (fs) treatment in some oxidative diseases have been reported. objective: this study aimed to evaluate the antioxidant effect of fs in prepubertal rats with experimental varicocele. materials and method...

OBJECTIVES: To determine the effect of testosterone administration to prepubertal (15 days old) and peripubertal rats (30 days old) on hypothalamic nitric oxide synthetase (NOS), and GnRH release. METHODS: Hypothalamic samples containing the anterior preoptic and medial basal areas (APO-MBH) were incubated for 30 minutes in 500 l of Earle’s medium with glucose (1 mg/ml) and bacitracin (20 mM). ...