Puvitha R. Duraisami* Department of Pathology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rare, benign, histiocytic proliferative disorder. It can be encountered in both nodal and extra nodal locations. Fine needle aspiration technique is a simple, accurate and most economic tool, being used wide...

Meningioma with extensive histiocytic changes is rare. We describe a case of histiocytic meningioma which occurred in a 55-year-old woman. The patient had a progressive headache and a decline in fine motor coordination and memory for the past four years. Magnetic resonance imaging demonstrated a well-demarcated, dura-based and contrast-enhancing mass lesion in the right superior frontoparietal ...

Rosai-Dorfman disease (RDD) is a rare benign histiocytic proliferative disorder predominantly of the lymph nodes, which mostly occurs in children and young adults typically presenting with lymphadenopathy. Our case is of a 63 year-old African-American male who presented with subjective fever, weight loss, bilateral axillary and inguinal lymphadenopathy as well as auto-immune hemolytic anemia. T...

Block 6 Level 9, Dermatology Unit, Singapore General Hospital, Outram Road, 169608, Singapore Langerhans cell histiocytosis (LCH) is a proliferative histiocytic disorder of unknown cause characterized by the accumulation of Langerhan cells in various tissues. Typically a disorder of childhood, features of this disease have been well documented in children but remain ambiguous and poorly documen...

There are few disease entities so confusing as those related to the histiomonocytic cells and their malignant proliferations, defined either as Malignant Histiocytosis or histiocytic lymphoma. Both terms have been considered synonymous and employed indifferently by most Authors, although certain differences in the clinical manifestations have sometimes been outlined. The term “malignant-histioc...

Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete ...

Histiocytic necrotizing lymphadenitis or Kikuchi's disease is a rare, benign condition of unknown etiology, which is usually characterized by cervical lymphadenopathy and fever. This disease is rarely associated with systemic lupus erythematosus. Here we describe, for the first time in Iran, a patient who developed systemic lupus erythematosus about 3 years after the initial diagnosis of Kikuch...

histiocytic necrotizing lymphadenitis or kikuchi's disease is a rare, benign condition of unknown etiology, which is usually characterized by cervical lymphadenopathy and fever. this disease is rarely associated with systemic lupus erythematosus. here we describe, for the first time in iran, a patient who developed systemic lupus erythematosus about 3 years after the initial diagnosis of kikuch...

Canine histiocytic malignancies represent a group of neoplasms with shared morphological features but diverse cellular origin and potentially divergent biologic behavior. The malignant histiocytic disease complex was first recognized in Bernese Mountain Dogs and it has been considered to be familial in this breed. Subsequently, improved diagnostic techniques expanded the list of predisposed bre...

langerhans cell histiocytosis (lch) is the most common type of childhood histiocytic disorder with an incidence of 0.2 to 1 per 100,000 children under the age of 15 years (1). the clinical picture of lch varies from single system (s-s)bone or skin disease to multi-system disease (m-s) (2). we report a neonate with disseminated papulonodular eruption containing mononuclear cd1a and s100 positive...