background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...

background and objectives: preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. high sensitive c - reactive protein (hs-crp) is a sensitive marker of inflammation. our aim in this study was to determine amniotic fluid hs-crp concentration and its correlation with pre-term delivery.   materials and methods: this prospective study was conducted on 90 pregna...

objective: to investigate the clinical advantage of several prognostic factors for predicting preterm delivery. materials and methods: eighty and six patients with a singleton pregnancy admitted to vali-asr hospital underwent genetic amniocentesis between the 15th and 23th weeks were included in this study. maternal serum c-reactive protein (crp), transvaginal sonographic measurement of cervica...

Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...

conclusions this study demonstrated that physicochemical properties, in vitro release and rat intestine permeability were dependent upon the contents of s/c, water and oil percentage in formulations. background self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polym...

objective(s): the aim of this work was to prepare and characterize magnetic nanoparticles (mnps) as theranostic system to act simultaneously as drug carrier and mri contrast agent. chitosan-coated mnps (cmnps) were prepared and loaded with silymarin. silymarin-loaded cmnps were characterized with various techniques and their potential as mri contrast agent was also evaluated. materials and meth...

Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...

Boronate Building Blocks building blocks have been developed for intracellular protein delivery. Article 2202049 by Qianyi Ren, Yiyun Cheng, and Jia Lv provides a summary of boronate chemistry used in the design cytosolic delivery systems. The can address barriers existing process.

curcumin is a natural polyphenolic compound with anti-cancer, anti-inflammatory, and anti-oxidation properties. low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin as therapeutic agent. in the current study, the role of the bovine serum albumin (bsa), β-lactoglobulin and casein, as food-grade biopolymers and safe drug delivery systems, on the physic...

...................................................................................................... iii Acknowledgements.................................................................................... vi Table of Figures.......................................................................................... xiii CHAPTER 1: INTRODUCTION......................................................