The glial fibrillary acidic protein (GFAP) is a type III intermediate filament (IF) that highly expressed in astrocytes, neural stem cells, and gliomas. Gliomas are heterogeneous group of primary brain tumors arise from glia cells or rely on accurate diagnosis for prognosis treatment strategies. GFAP differentially between glioma subtypes and, therefore, often used as diagnostic marker. However...

PurposeAlternative ribonucleic acid (RNA) transcript splicing produces multiple RNA isoforms from the same gene which are associated with many heart diseases. However, little is known about alternative events in donor hearts during cold preservation.MethodsWe examined transcriptomic profile of left ventricle human comparing 0 and 8 hours preservation histidine-tryptophan-ketoglutarate solution....

Abstract Prostate cancer (PCa) is a highly heterogeneous and unpredictable progressive disease. Sensitivity of PCa cells to androgens play central role in tumor aggressiveness but biomarkers with high sensitivity specificity that follow the progression disease has not yet been verified. The vitamin D endocrine system its receptors, Vitamin Receptor (VDR) Protein Disulfide-Isomerase A3 (PDIA3), ...

Different external stimuli are perceived by multiple sensor histidine kinases and transmitted phosphorylation via the phosphotransfer protein Ypd1p in multistep phosphorelay system of high osmolarity glycerol signaling pathway filamentous fungi. How signal propagation takes place is still not known detail since kinase genes most fungi coded genome, whereas only one gene for exists. That raises ...

The transcription of mammalian genomes exhibits an intriguing complexity and numerous novel RNA molecules have been identified. Viruses with large DNA genomes, especially herpesviruses, generate many different species, including long non-coding RNAs (lncRNAs). Dense viral can multigenic transcripts in addition to commonly observed antisense transcripts. It is essential study the biological role...