Hydroalcoholic extract of Pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. As P. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. Therefore, the aim of this study was to determine the effect of P. spinosa extract on rat bladder contraction. In an in vitro study, the effects of P. spinosa extract, nifedipine ...

Bioassay monitoring of hydroalcoholic extract from the aerial part of Pyconcycla spinosa revealed that it contains components with spasmolytic activity in vitro. In addition, P. spinosa extract at oral dose of 1-5 mg/kg inhibits diarrhoea in animal models. Pharmacological screening of pure compounds isolated from P. spinosa hydroalcoholic extract led to the identification of 3,7,10,14,15-pentaa...

pharmacological activities of 6-(4-hydroxy-3-methoxyphenyl)-hexanonic acid (hmpha), a phenolic compound, isolated from the extract of pycnocycla spinosa was investigated on ileum motility in vivo and in vitro . ileum motility was examined by measuring charcoal movement through the gut in mice. in addition, antidiarrhoeal activity of hmpha was assessed and compared with standard drug; loperamide...

     Cell cultures of Varthemia persica, Peganum harmala and Pycnocycla spinosa have been studied to evaluate their abilities to bioconvert exogenous hydroquinone. Arbutin is an important substance that has several pharmaceutical applications; therefore, we have established V. persica and P. spinosa cultures which seem to be able to metabolize hydroquinone. C...

abstract   extract prepared from aerial part of pycnocycla spinosa is a relaxant of rat ileum contractions. the objective of this research was to study the spasmolytic activity of p. spinosa root extract for comparison with the aerial part extract. hydroalcoholic extracts were prepared by percolation method. a portion of rat ileum was removed and suspended under 1 g tension in tyrode’s solution...

isovanillin and iso-acetovanillon are two phenolic components isolated from a number of plants including pycnocycla spinosa . p. spinosa extract has antispasmodic and antidiarrheal activities. however, no comparative study has been done on antidiarrheal action of isovanillin and iso- acetovanillon, so far. the aim of this study was to investigate antidiarrheal action of isovanillin and iso-acet...

Pycnocycla spinosa aerial parts were collected weekly during four-month growth. Hydrodistillation and gas chromatography coupled with mass spectroscopy techniques were used for essential oil and sesquiterpenes investigation. Thirty-four components were identified, of which the characteristic sesquiterpenes were a -copaene, caryophyllene, a -humulene, b-ionene, d-cadinene, a -calacorene, caryoph...

Pycnocycla spinosa aerial parts were collected weekly during four-month growth. Hydrodistillation and gas chromatography coupled with mass spectroscopy techniques were used for essential oil and sesquiterpenes investigation. Thirty-four components were identified, of which the characteristic sesquiterpenes were a -copaene, caryophyllene, a -humulene, b-ionene, d-cadinene, a -calacorene, caryoph...

Over the past decades, there has been increasing attention on polyphenol-rich foods including fruits and vegetables on human health. Polyphenols have been shown to possess some potential beneficial effects on human health and they are widely found in foods consumed by populations worldwide. Capparis spinosa (C. spinosa) is an important source of different secondary metabolites of interest to hu...