The vertebrate hindbrain is transiently divided along the anterior-posterior axis into seven morphologically and molecularly distinct segments, or rhombomeres, that correspond to Hox expression domains. The establishment of a proper 'hox code' is required for the development of unique rhombomere identities, including specification of neuronal fates. valentino (val), the zebrafish ortholog of ma...

Soft errors induced by radiation, causing anomalies in satellite equipment and spacecrafts, have become one of the most challenging issues that impact the reliability of modern processors even in ground-level applications. In this work, we investigate the feasibility of using ARM Cortex-R4 CPU for space and avionics applications. We create a single-event upset and transient tolerant variant Cor...

BACKGROUND Video-assisted thoracoscopic sympathicotomy has been determined to be the best way to treat palmar hyperhidrosis. However, satisfaction with the surgical outcomes decreases with the onset of compensatory hyperhidrosis (CH) over time. The ideal level of sympathicotomy is controversial. Therefore, we compared the long-term results of R3 and R4 sympathicotomy. METHODS We retrospective...

Two rainbow trout chemokine receptors have been sequenced, with homology to CXC-R4 and CC-R7 molecules. The CXC-R4 sequence consisted of 1681 nucleotides, which translated into a mature protein of 357 amino acids, with 80.7% similarity to human CXC-R4. The CC-R7 sequence consisted of 2287 nucleotides, which translated into a 368-amino acid mature protein with 64.5% similarity to human CC-R7. Bo...

BACKGROUND TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightly controlled by two antagonistic receptors, TRAIL-R3 and TRAIL-R4, both devoid of a functional death domain, an intracellular region of the receptor, required for the recruitment and the activation of...

We exposed st.10 chicks to retinoic acid (RA), both globally, and locally to individual rhombomeres, to look at its role in specification of various aspects of hindbrain derived morphology. Previous studies have looked at RA exposure at earlier stages, during axial specification. Stage 10 is the time of morphological segmentation of the hindbrain and is just prior to neural crest migration. Rho...

The enzyme kinetic profiles of the formation of resveratrol-3-O-glucuronide (R3G) and resveratrol-4'-O-glucuronide (R4'G) by liver microsomes from humans, dogs, and rodents were investigated. Glucuronidation by human and dog liver microsomes to R3G and R4'G occurred for about 65% of applied resveratrol, and was significantly reduced to 10% when substrate concentration was increased 10-fold. In ...

The Ramsey number R(G1, G2, G3) is the smallest positive integer n such that for all 3-colorings of the edges of Kn there is a monochromatic G1 in the first color, G2 in the second color, or G3 in the third color. We study the bounds on various 3-color Ramsey numbers R(G1, G2, G3), where Gi ∈ {K3,K3 + e,K4 − e,K4}. The minimal and maximal combinations of Gi’s correspond to the classical Ramsey ...

In this paper T , U are non empty topological spaces, t is a point of T , and n is a natural number. Let S be a topological space and let T be a non empty topological space. Note that every function from S into T which is constant is also continuous. The following two propositions are true: (1) L01(0, 1, 0, 1) = id[0, 1]T . (2) For all real numbers r1, r2, r3, r4, r5, r6 such that r1 < r2 and r...