نتایج جستجو برای: rank ligand
تعداد نتایج: 178783 فیلتر نتایج به سال:
objective: receptor activator of nuclear factor-kappa b ligand (rankl) appears to be an osteoclast-activating factor, bearing an important role in the pathogenesis of multiple myeloma. some studies demonstrated that u-266 myeloma cell line and primary myeloma cells expressed rank and rankl. it had been reported that the expression of myeloid and monocytoid markers was increased by co-culturing ...
Familial expansile osteolysis and related disorders are caused by heterozygous tandem duplication mutations in the signal peptide region of the gene encoding receptor activator of NF-κB (RANK), a receptor critical for osteoclast formation and function. Previous studies have shown that overexpression of these mutant proteins causes constitutive activation of NF-κB signaling in vitro, and it has ...
Molecular docking is widely used to discovery novel ligands in structure-based drug design (SBDD) [1]. Over the past 15 years, various docking programs have been developed. Generally, flexible docking programs, such as DOCK, AutoDock, FlexX, GOLD and Glide, have the ability to predict protein-ligand complex structures with reasonable accuracy and speed. These docking programs are aimed at predi...
The contributions of IFN regulatory factor (IRF) 3/7 and the type I IFNs IFN-α/β to the innate host defense have been extensively investigated; however, their role in thymic development is less clear. In this study, we show that mice lacking the type I IFN receptor IFN-α/β receptor (IFNAR) or the downstream transcription factor STAT1 harbor a significant reduction in self-Ag-presenting, autoimm...
چکیده : مالتیپل میلوما بدخیمی خونی است که با افزایش تکثیر پلاسماسل های مونوکلونال در مغز استخوان همراه می باشد . ضایعات استئولیتیک این بیماری موجب دردهای شدید استخوانی ، شکستگی های پاتولوژیک استخوانی ، افزایش کلسیم و فشردگی طناب نخاعی می گردد . مکانیسم سلولی اصلی که باعث ایجاد بیماری استخوانی در میلوما می شود شامل واکنش متقابل بین سلول میلومایی و ریز محیط مغز استخوان (microenviroment ) می باش...
We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes. RANK(-/-) mice lack osteoclasts and have a profound defect in bone resorption and remodeling and in the development of the cartilaginous growth plates of endochondral b...
The receptor activator of nuclear factor-kappaB ligand (RANKL; also known as tumor necrosis factor-related activation-induced cytokine [TRANCE], osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]) is a transmembrane ligand expressed in osteoblasts and bone marrow stromal cells. It binds to RANK, which is expressed in osteoclast progenitor cells, and induces osteoclastoge...
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