Sera from approximately two-thirds of patients with rheumatoid arthritis contain an antibody which is reactive with a nuclear antigen present in human B-lymphocyte tissue culture cells. The immunological reaction can be demonstrated by precipitation and immunofluorescence. Evidence is present that the reactive nuclear antigen is associated with Epstein-Barr (EB) virus-transformed lymphocytes. N...

Background: SARS-COV-2 pandemic is a serious health problem all over the world including Egypt, thus realizing predictive factors and disease’s characteristics an essential issue.Objectives: To evaluate of laboratory-confirmed cases SARS-CoV-2 infection in Fayoum governorate, to determine disease severity.Methods: 140 patients confirmed with from were collected this descriptive multicenter stud...

Monoclonal antibody to LeuM1, a granulocyte-related differentiation antigen, represents a highly effective reagent for detection of diagnostic "Reed-Sternberg" cells and variants in paraffin-embedded tissues of Hodgkin's disease. The "Reed Sternberg" cell in all the cases of Hodgkin's disease except lymphocyte predominance variety revealed positive intracytoplasmic/paranuclear granular staining...

OBJECTIVE Cerebrospinal fluid (CSF) examination is mandatory whenever central nervous system (CNS) infection is suspected. However, pleocytosis is not detected in a substantial number of suspected patients who undergo CSF examination. This study aimed to identify parameters that can aid in predicting negative CSF examination results (defined as a white blood cell count of <5 cells/high-power fi...

SUMMARY OBJECTIVE: This retrospective study aimed to determine the predictive values of C-reactive protein (CRP)/albumin ratio (CAR), fibrinogen/albumin (FAR), and neutrophil/lymphocyte (NLR) parameters, which reflect systemic inflammatory status, for severity COVID-19. METHODS: A total 188 patients diagnosed with COVID-19 were enrolled in this study. Among them, 118 severe group, 70 non-severe...

The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), and eosinophil count have been used as biomarkers of immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI) treatment. As no report has yet compared by the affected organs, we explored this topic. A total 284 patients on ICIs included 102 irAEs 182 without. following comparisons were statistically...

Neutrophil-to-Lymphocyte ratio (NLR) is a simple parameter used for easy assessment of the inflammatory status subject. NLR calculated by dividing absolute neutrophil count definite lymphocyte count. reflects balance between innate and adaptive immune systems. Recently, has been as an essential biomarker inflammation, infections, postoperative complications displayed correlation with circulatin...

Background: Low vitamin D has been linked to enhance inflammatory markers in various pathological conditions. We aimed to evaluate the urinary tract infection (UTI)-associated hematological and inflammatory markers mediated by low serum levels of 25-hydroxyvitamin D [25(OH)D]. Methods: Vitamin D level, hematological indices (Neutrophil-to-lymphocyte ratio [NLR], Monocyte-to-lymphocyte ratio [M...

The cross-reactivity of four Coccidioides antigens, three Histoplasma antigens, and two Blastomyces antigens were determined in lymphocyte transformation assays of 11 coccidioidin-reactive, histoplasmin-nonreactive subjects (group I), 13 coccidioidin-nonreactive, histoplasmin-reactive persons (group II), and 13 subjects who were skin test negative to both antigens (group III). Mycelial and yeas...