To the Editor—It was with interest that we read the study by Frey et al. [1], which describes a randomized trial in which 3 manufacturing consistency lots of a combined hepatitis A and B vaccine were compared with the corresponding monovalent vaccines. The authors observed a nonsatisfactory response to the hepatitis B component in the combined vaccine. We are concerned that this report may be m...

one of the most important aspects in recombinant biologic production, based on gmp rules, is the accuracy of final product quality control, especially assessment of host cell macromolecules contamination rate in final product. the purification requirement can be eliminated when the yeast cell containing the recombinant protein is used as a host cell. it is possibile that the final product conta...

abstract        background and objective: aluminum salts are among the most common useful additive compounds in preparation of human and animal vaccines. aluminum phosphate and aluminum hydroxide are two additives that show good immunoadjuvant effects with many antigens. aluminum-containing vaccines lead to a better and longer immune response compared to adjuvant-lacking vaccines. the chromogen...

background & objectives: hepatitis b is one of the major health problems in the world. health care workers (hcws) are at high risk of acquiring hepatitis b virus. the aim of this study was to evaluate the prevalence of hbv infection and the immune response to hbv vaccine among the hcws in babol, northern iran. methods: this study was accomplished on 527 hcws and administrative staff working...

conclusions hbv vaccination in infancy is effective at preventing chronic hbv infection but is less effective at preventing occult hbv infection. similar studies examining the efficacy of adult hbv vaccination in preventing occult hbv have not been performed. this case highlights the importance of carefully determining the hbv status of high-risk individuals, as vaccination history and the pres...

A 52-year-old woman developed Guillain-Barré syndrome 10 weeks after immunization with recombinant hepatitis B vaccine. Common infectious causes of GBS were ruled out. The temporal relationship between GBS and hepatitis B virus (HBV) vaccination was suggestive of a vaccine-induced cause. The possible mechanisms of this very, rare complication are discussed.

BACKGROUND Hepatitis B is a major public health problem, which has now been controlled to some extent by vaccination especially with the recombinant hepatitis B vaccine, which has been proven to be safe and efficacious since its introduction in the 1990s. But problems of unsafe injection practices still persist. Now newer delivery devices like uniject are available for making vaccination very s...

Hepatitis B virus (HBV) is an etiological agent of hepatitis B infection. Hepatitis B is a life-threatening disease that affects the liver. The clinical outcomes of the disease are varied from asymptomatic disease to serious complication such as cirrhosis and hepatocellular carcinoma (HCC). Despite availability of the vaccine and appropriate treatment, hepatitis B infection still remains a majo...

Background: Thalassemia patients are more susceptible to hepatitis than the normal population due to the frequent blood transfusions. Objective: To determine the immune response of children with major ß-thalassemia, by measuring anti-hepatitis B surface antibody (anti-HBs Ab) following the last HBV vaccine injection. Methods: This study was carried out on 215 thalassemic children who received t...