Recurrent pregnancy loss (RPL) is defined as 3 or more consecutive pregnancy losses prior to 20 th week of gestation. The prevalence of recurrent pregnancy loss is 1% to 3% of pregnancies. RPL is a challenging medical problem because of its unknown pathogenesis and etiology in most of the cases. Environmental contaminant may adversely affect the human reproductive health includes heavy metals, ...

AIM To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian population. SETTINGS AND DESIGN The study included 163 non-pregnant women with recurrent pregnancy loss in a gestational age up to <or=12 weeks verified by a pregnancy test or ultrasonography, and a total of 170 age matched women with at least one successful pregnancy and n...

Recurrent pregnancy loss (RPL) has many known aetiologies. However, using current diagnostic testing, a large fraction of recurrent pregnancy losses remain unexplained. Many of these may have immune underpinnings. HLA-G is a non-classical MHC class I product whose fairly restricted expression at the maternal-fetal interface suggests a role in successful embryonic implantation and/or subsequent ...

In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication suc...

BACKGROUND To date, the role of male factor contributing in evaluation of spontaneous recurrent pregnancy loss (RPL) has been less investigated and there is discrepancy in the role of Y chromosome microdeltions in RPL. Therefore, the current study was designed to examine whether Y chromosome microdeletions were associated with RPL in an Iranian population. METHODS One hundred men from couples...

Introduction: Recurrent Pregnancy Loss (RPL) is a heterogeneous disease which consisting of three or more successive abortions before 20 weeks of pregnancy. The cytokines that secreted by Th1 cells (IL-1, TNFα and IFNγ) were described as etiologic factors in RPL. The aim of this study was investigate to association between recurrent pregnancy loss and IL-1 receptor antagonist gene (IL-1RN) intr...

background: recurrent pregnancy loss (rpl) caused by various genetic and non-genetic factors. after chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause rpl. factor v leiden and factor ii g20210a mutation were the most common mutations cause thrombophilia in the world. objective: the purpose of this study was to determine the frequency of factor v ...

background: spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. angiotensin converting enzyme (ace) converts angiotensin i to angiotensin ii and is involved in thrombosis. the most common polymorphism in this gene is the inse...