Mesenchymal Stem Cells (MSCs), often referred to as stromal cells have been the focus in regenerative medicine for their immune suppressive ability, their ability to hone in on the site of injury, their ability to differentiate into multiple cell lines, and ease of cell culture expansion. MSCs have the ability to differentiate into a range of specialized cells of mesodermal origin bone, cartila...

Recently, the accessory limb model (ALM) has become an alternative study system for limb regeneration studies in axolotls instead of using an amputated limb. ALM progresses limb regeneration study in axolotls because of its advantages. To apply and/or to compare knowledge in axolotl ALM studies to other vertebrates is a conceivable next step. First, Xenopus laevis, an anuran amphibian, was inve...

Echinoderms represent a phylum with exceptional regenerative capabilities that can reconstruct both external appendages and internal organs. Mechanistic understanding of the cellular pathways involved in regeneration in these animals has been hampered by the limited genomic tools and limited ability to manipulate regenerative processes. We present a functional assay to investigate mechanisms of...

Regenerative Vascular Tissue Engineering In article number 2200050, Quinton Smith and co-workers review strategies for regenerative vascular tissue engineering. The vasculature is a conduit that links various organ systems, guiding development, homeostasis, regeneration. They reflect in this cover the ability of cells (green endothelial cells) to self-assemble interact with parenchymal (red, st...

the stem cells can be considered as the miracle of creation, because, they are a major reservoir of the bioactive factors, molecules and cells. these reservoir cells play a major role in development and growth of the tissues and organs. regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic appl...

The inner ear contains six distinct sensory organs that each maintains some ability to regenerate hair cells into adulthood. In the postnatal cochlea, there appears to be a relationship between the developmental maturity of a region and its ability to regenerate as postnatal regeneration largely occurs in the apical turn, which is the last region to differentiate and mature during development. ...