The emergence and spread of antimicrobial resistance (AMR) is still an unresolved problem worldwide. In intensive care units (ICUs), first-line antibiotic therapy is highly standardized and widely empiric while treatment failure because of AMR often has severe consequences. Simultaneously, there is a limited number of reserve antibiotics, whose prices and/or side effects are substantially highe...

Development of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Carbapenem pr...

Development of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Carbapenem pr...

background in recent decades, multidrug-resistant non-fermenting gram-negative pathogens, particularly acinetobacter baumannii and pseudomonas aeruginosa, have been recognized as a major cause of healthcare-associated and nosocomial infections and outbreaks. conclusions the majority of a. baumannii and p. aeruginosa isolates were found to be resistant to commonly recommended antibiotics. theref...

PURPOSE OF REVIEW The prevalence of multidrug-resistant organisms (MDROs) in ICUs is increasing worldwide. This review assesses the role of infection control measures, excluding antibiotic stewardship programs, in reducing the burden of resistance in ICUs. RECENT FINDINGS The knowledge base about the effect of increased hand hygiene compliance in reducing the burden of methicillin-resistant S...

development of antibiotic resistance in intensive care units (icus) is a worldwide problem. the purpose of this study was to evaluate the effect of an antibiotic stewardship program (asp) by carbapenems restriction on gram-negative antimicrobial resistance in icu. the study was designed in a 21 bedded general icu of a teaching hospital with two wings (one and two) in tehran, iran. carbapenem pr...

Antimicrobial resistance has emerged as an important variable influencing patient mortality and overall resource use in the hospital setting (1). Intensive care units (ICUs) worldwide are faced with increasingly rapid emergence and spread of antibiotic-resistant bacteria. Both antibiotic-resistant Gramnegative and Gram-positive bacteria are reported as important causes of hospital-acquired infe...

Background and Objective: Pseudomonas aeruginosa has become a frequent cause of nosocomial infections, particularly in intensive care units (ICUs). Many reports have documented high rates of resistance in this species to commonly-used broad-spectrum antibiotics. The aim of this study was to assess the in vitro activity of some a...