Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal-dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), explori...

an experiment was conducted in algerian desert goats to study the effect of age and season on blood biochemical and mineral profile during different physiological stages of the goats. serum ca, mg and na levels were significantly high at birth and decreases as the age advanced. the season had a significant effect on the decreased levels of ca, mg and k and inversely on the increased levels of n...

A total of 2,880 pigs (PIC 327 × L42; initial BW 11.4 lb) were used in a 35-d growth performance trial evaluating the effects of dietary electrolyte balance (dEB) on growth performance of nursery pigs. There were 30 pigs per pen (60 pigs per double-sided feeder) and 12 replications (feeder) per treatment. Pens of pigs were allotted by BW and sex on arrival, and randomly assigned to 1 of 4 dieta...

      Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...

An experiment was conducted in Algerian desert goats to study the effect of age and season on blood biochemical and mineral profile during different physiological stages of the goats. Serum Ca, Mg and Na levels were significantly high at birth and decreases as the age advanced. The season had a significant effect on the decreased levels of Ca, Mg and K and inversely on the increased levels of N...

Monolayer cultures of rat fetal distal lung epithelial (FDLE) cells generated larger spontaneous short circuit currents (ISC) when maintained (48 h) at neonatal alveolar PO2 (100 mmHg) than at fetal PO2 (23 mmHg). When cells were shifted between these atmospheres in order to impose a rise in PO2 equivalent to that seen at birth, no rise in ISC was seen after 6 h but the response was fully estab...

Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased ...

1,2,3,4-Diepoxybutane (DEB) is a bifunctional electrophile capable of forming DNA-DNA and DNA-protein cross-links. DNA alkylation by DEB produces N7-(2'-hydroxy-3',4'-epoxybut-1'-yl)-guanine monoadducts, which can then form 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) lesions. All three optical isomers of DEB are produced metabolically from 1,3-butadiene, but S,S-DEB is the most cytotoxic an...

The main feature of Fanconi anemia (FA) is the high sensitivity of the cells to the clastogenic agent, diepoxybutane (DEB). Thus, differential diagnosis of this syndrome can be made by cytogenetic analysis; adding DEB to lymphocytes in culture (DEB test) increases the number of chromosome breaks. Fanconi anemia cells have an abnormal cell cycle, with an increased frequency of cells arrested at ...