Previously we had developed a triple gene mutant of Mycobacterium tuberculosis (MtbΔmms) harboring disruption in three genes, namely mptpA, mptpB and sapM Though vaccination with MtbΔmms strain induced protection in the lungs of guinea pigs, the mutant strain failed to control the hematogenous spread of the challenge strain to the spleen. Additionally, inoculation with MtbΔmms resulted in some ...

In this chapter, the performance improvement obtained from phase modulation (PM) and filtering on return-to-zero (RZ) signal format at the transmitter is investigated. The primary purpose is to understand the mechanism of each type of PM that leads to performance improvement relative to the RZ signal format with no PM. Three types of phase modulation on an RZ pulse train are considered in this ...

BACKGROUND Several countries are considering a minimum price policy for alcohol, but concerns exist about the potential effects on drinkers with low incomes. We aimed to assess the effect of a £0·45 minimum unit price (1 unit is 8 g/10 mL ethanol) in England across the income and socioeconomic distributions. METHODS We used the Sheffield Alcohol Policy Model (SAPM) version 2.6, a causal, dete...

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death due to bacterial infections in mankind, and BCG, an attenuated strain of Mycobacterium bovis, is an approved vaccine. BCG sequesters in immature phagosomes of antigen presenting cells (APCs), which do not fuse with lysosomes, leading to decreased antigen processing and reduced Th1 responses. However, an...

BACKGROUND The failure of Mycobacterium bovis Bacille Calmette-Guérin to impart satisfactory protection against adult pulmonary tuberculosis has necessitated the development of more effective TB vaccines. The assumption that the vaccine strain should be antigenically as similar as possible to the disease causing pathogen has led to the evaluation of M.tuberculosis mutants as candidate tuberculo...

Dormancy is defined as a stable but reversible nonreplicating state of Mycobacterium tuberculosis. It is currently thought that dormant M. tuberculosis (D-Mtb) is responsible for latent tuberculosis (TB) infection. Recently, D-Mtb was also shown in sputa of patients with active TB, but the capacity of D-Mtb to stimulate specific immune responses was not investigated. We observed that purified p...

This study is the first report of numerical solution of nonlinear bending analysis for annular and circular plates based on 3D elasticity theory with asymmetric boundary conditions using semi-analytical polynomial method (SAPM). Orthotropic annular and circular plates are subjected to transverse loading and 3D bending analysis in the presence of symmetric and asymmetric boundary conditions is s...