BACKGROUND Computerized Physician Order Entry (CPOE) analgesia-sedation protocols may improve sedation practice and patients' outcomes. We aimed to evaluate the impact of the introduction of CPOE protocol. METHODS This was a prospective, observational cohort study of adult patients receiving mechanical ventilation, requiring intravenous infusion of analgesics and/or sedatives, and expected to...

OBJECTIVE To evaluate the effect of a nursing-driven sedation protocol for mechanically ventilated pediatric patients on duration of use of analgesic and sedative medications. We hypothesized that a protocol would decrease length of sedation use and decrease days of mechanical ventilation and length of stay. DESIGN Retrospective cohort study with historical controls. SETTING Thirty-one-bed ...

OBJECTIVE To evaluate the implementation of a neonatal pain and sedation protocol at 2 ICUs. METHODS The intervention started with the evaluation of local practice, problems, and staff satisfaction. We then developed and implemented the Vienna Protocol for Neonatal Pain and Sedation. The protocol included well-defined strategies for both nonpharmacologic and pharmacologic interventions based ...

BACKGROUND Optimal sedation and analgesia is a challenge in paediatric intensive care units (PICU) because of difficulties in scoring systems and specific metabolism inducing tolerance and withdrawal. Excessive sedation is associated with prolonged mechanical ventilation and hospitalisation. Adult and paediatric data suggest that goal-directed sedation algorithms reduce the duration of mechanic...

Objective: The aim of this study was to systematically review studies that compared a mild target sedation protocol with daily sedation interruption and to perform a meta-analysis with the data presented in these studies. Methods: We searched Medline, Scopus and Web of Science databases to identify randomized clinical trials comparing sedation protocols with daily sedation interruption in cri...

conclusions propofol provided a safe and acceptable sedation for post-cabg surgical patients, significantly reduced the requirement for analgesics, and allowed for more rapid tracheal extubation than midazolam but did not result in earlier icu discharge. results the depth of sedation was almost the same in the two groups (rss=4.5 in midazolam group vs 4.7 in propofol group; p = 0.259) but the t...

Heavy sedation in the ICU is associated with coma, delirium, and prolonged stays, but links between sedatives and non-brain organ failure have rarely been described. In a post hoc analysis, Strøm and colleagues explored associations between sedation and acute kidney injury among ICU patients randomly assigned to one of two sedation strategies. The 'no sedation' protocol was associated with less...

ABSTRACT A study was designed to compare two sedation protocols be used in horses undergoing orchiectomy when standing. In both protocols, the induction sedative state performed with bolus detomidine at a dose of 10 µg/kg, intravenously (IV). first protocol (eight horses), maintained 1% glyceryl guaiacol ether (GGE) continuous infusion, 1ml/kg/hour IV. second horses) this effect infusion same a...

OBJECTIVE This large-scale retrospective review evaluates the sedation profile of dexmedetomidine. AIM To determine the hemodynamic responses, efficacy and adverse events associated with the use of high dose dexmedetomidine as the sole sedative for magnetic resonance imaging (MRI) studies. BACKGROUND Dexmedetomidine has been used at our institution since 2005 to provide sedation for pediatr...