Abstract Background: Molecular imprinting is a method for synthesizing polymers with structure-selective adsorption properties with applications such as, selectivity binding, drug delivery systems and anti-bodies. The present study aims at optimizing the preparation of molecularly imprinted polymer (MIP) against l-phenylalanine, in order to increase phenylalanine-binding in Enzymatic Intestinal...

We present a biologically plausible computational model for solving the visual binding problem. The binding problem appears due to the distributed nature of visual processing in the primate brain, and the gradual loss of spatial information along the processing hierarchy. The model relies on the reentrant connections so ubiquitous in the primate brain to recover spatial information, and thus al...

to obtain drugs which are more selective at benzodiazepine (bzd) receptors, design and synthesis of functionally selective ligands for bzd receptors is the current strategy of our pharmaceutical chemistry department. the affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Cell-Selective Spider Silk Proteins In article number 2202660, Vanessa Tanja Trossmann and Thomas Scheibel design recombinant spider silk proteins to guide cell-specific materials interactions. The fusion of with short peptides from extracellular matrix such as KGD yield cell type selective binding, which enables the development hierarchically organized tissues.

Abstract Platinum-binding peptides have been used for fabrication of complex platinum nanomaterials such as catalysts, metallopharmaceuticals, and electrodes. In this review, we present understanding the mechanisms behind platinum-binding (Pt-binding) applications multifunctional biomaterials. We discuss how surface recognition, roles individual amino acids, arrangement acid sequences interplay...

Density functional theory dispersion corrected (DFT-D3)calculations and molecular dynamic (MD) simulation were applied to investigate the sensing ability of four types of receptors (RCs) composed of the ortho-phenylenediamine based bis-ureas for selective complexation with the anions such as Cl–, Br–, OAC–, PhCO2–, H2PO4– and HSO4– in the gas phase and DMSO. On the basis of the data obtained fr...

A new series of peptide-like derivatives containing different aromatic amino acids andpossessing pharmacophores of COX-2 inhibitors as SO2Me or N3 attached to the para positionof an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2)inhibitors. The synthetic reactions were based on the solid phase peptide synthesis methodusing Wang resin. One of the analogues, i...