Plant growth promoting rhizobacteria (PGPR) mediate the soil processes such as decomposition, nutrient mobilization, mineralization, solubilization, nitrogen fixation and growth hormone production. Microorganisms having the phosphate solubilizing capacity can convert the insoluble phosphates into soluble forms through the production of organic acids. Inoculation of seed with P-solubilizing micr...

A diverse and versatile spectrum of metabolic activities among isolates of fluorescent Pseudomonas putida indicates their adaptability to various niches. These polyhydroxybutyrate producing and phosphate solubilizing isolates showed a high level of functional and genetic versatility among themselves. One of the potential P. putida isolate P132 can contribute as a candidate agent for both biocon...

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX), the enzyme responsible for the first step in synthesis of various prostaglandins (PGs) from arachidonic acid. COX exists as two isoforms, COX-1, which is constitutively present in almost all cells and produces PGs concerned with protection of the gastric mucosa and kidney functions, and COX-2, which ...

Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cre...

Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like 'top-down' fine milling of excipient-free injectable drug suspensions are not yet clinically viable and 'bottom-up' self-assembled delivery systems usually substitute one solubilizing excipient for another, bringing new issues to consider. Here, ...