OBJECTIVES Bacterial resistance to antibiotics, driven by antibiotic consumption, imposes a major threat to the effective treatment of bacterial infections. In addition to reducing the amount of antibiotics prescribed, avoiding broad-spectrum antibiotics could extend the lifetime of the current arsenal of antibiotic substances. Therefore, we documented prescriber and patient characteristics ass...

OBJECTIVE The aim of the study was to review evidence-based data regarding the use of antibiotics for the treatment of appendicitis in children. DATA SOURCE Data were obtained from PubMed, MEDLINE, and citation review. STUDY SELECTION We conducted a literature search using "appendicitis" combined with "antibiotics" with children as the target patient population. Studies were selected based ...

background: historically open surgical drainage has been the treatment of choice for pyogenic liver abscess. the records of 54 patients with pyogenic liver abscess were reviewed to determine whether earlier diagnosis with current imaging tests and definitive treatment with antibiotics and aspiration drainage was an effective alternative to surgery. methods: the clinical features, laboratory tes...

Background: Historically open surgical drainage has been the treatment of choice for pyogenic liver abscess. The records of 54 patients with pyogenic liver abscess were reviewed to determine whether earlier diagnosis with current imaging tests and definitive treatment with antibiotics and aspiration drainage was an effective alternative to surgery. Methods: The clinical features, laborator...

No therapeutically useful new classes of antibiotics have been identified in the past quarter of a century This has become of major consequence in the face of the increase in the incidence of significant antibiotic resistance in the past decade. Indeed, strains of several important pathogens have been identified for which very few, or even no, possibilities for antibiotic therapy exist. Althoug...

BACKGROUND AND OBJECTIVES Appendicitis guidelines recommend either narrower- or extended-spectrum antibiotics for treatment of complicated appendicitis. The goal of this study was to compare the effectiveness of extended-spectrum versus narrower-spectrum antibiotics for children with appendicitis. METHODS We performed a retrospective cohort study of children aged 3 to 18 years discharged betw...

Antimicrobial stewardship programs (ASPs) focus on improving the utilization of broad spectrum antibiotics to decrease the incidence of multidrug-resistant Gram positive and Gram negative pathogens. Hospital admission for both medical and surgical intra-abdominal infections (IAIs) commonly results in the empiric use of broad spectrum antibiotics such as fluoroquinolones, beta-lactam beta-lactam...

OBJECTIVE To evaluate physician and pharmacist knowledge on potential drug interactions between combined oral contraceptives (COC) and broad-spectrum antibiotics and determine if any difference exists between responses. METHODS Two hundred licensed retail pharmacists and 200 licensed family practice physicians in the states of Virginia, West Virginia, and Maryland were mailed an anonymous sur...