Provided the intragastric pH is greater than 6 and the collected gastric juice is boiled and neutralised immediately, considerable amounts of gastrin-like immunoreactivity can be found in human gastric juice. Characterisation according to size and charge reveals that nearly all the gastrin-like immunoreactivity is similar to gastrin 1-17. Direct stimulation of the G-cells with protein solution ...

P ROOF for the existence of a hormonal mechanism for gastric secretion has, until now, been lacking. Strong but nevertheless inconclusive evidence for the existence of such a hormone has long been available, but evidence that can be considered crucial has not been adduced. The status of the problem up to the time of the present studies has been clearly and extensively reviewed (1-4). In broad o...

Pepsin, acid and Helicobacter pylori are major factors in the pathophysiology of peptic ulcer disease and reflux oesophagitis. Ecabet sodium reduces the survival of H. pylori in the stomach and inhibits pepsin activity in the gastric juice of experimental animals. Here we have investigated the effects of ecabet sodium on some of the factors involved in the dynamics of the mucosal barrier, i.e. ...

We studied the distribution of pancreatic secretory trypsin inhibitor (PSTI) in the epithelia of the gastrointestinal tract and determined whether PSTI is secreted into gastric juice. PSTI was measured by a specific radioimmunoassay in biopsy specimens taken from the upper (n = 8) and lower (n = 7) gastrointestinal tract of patients with normal endoscopies. PSTI was present in the stomach, smal...

BACKGROUND TFF2, a member of the trefoil factor family (TFF) of peptides, is a secreted protein of 106 amino acids that is expressed in mucous neck cells of the fundus and glands at the base of the antrum in normal human stomach. TFF2 is also detected at high concentrations around sites of ulceration. It is protective against mucosal damaging agents and stimulates cell motility. AIMS To measu...

We studied the distribution of pancreatic secretory trypsin inhibitor (PSTI) in the epithelia of the gastrointestinal tract and determined whether PSTI is secreted into gastric juice. PSTI was measured by a specific radioimmunoassay in biopsy specimens taken from the upper (n=8) and lower (n=7) gastrointestinal tract of patients with normal endoscopies. PSTI was present in the stomach, small in...

The suspected link between nitrite and gastric cancer has led to several reports on the relation between pH and nitrite concentration in human gastric juice.' 3 Several methods have been used to estimate nitrite in biological fluid. Chemiluminescent4 and polarographic3 techniques both require complex equipment. The commonest methods described are based on the colour reaction of Greiss. These re...

1. The frequency of occurrence, under defined conditions, of the different human pepsins in the gastric juices of 50 normal subjects was investigated by agar-gel electrophoresis. 2. From a total of eight proteolytic zones located in the zymograms, no significant differences of occurrence existed between the sexes, or between subjects with or without gastric symptoms. 3. Two zones, numbered 3 an...

EDITORIAL SYNOPSIS The evidence presented here favours the possibility that gastric ammonium is produced from the urea in the blood through the action of a non-bacterial gastric urease. It also originates from blood ammonium which is transferred from blood into the gastric juice, the amount depending upon the level of the blood ammonium and the pH gradient between blood and gastric juice and th...