Some of the variety of Streptococcus pyogenes and Streptococcus dysgalactiae ssp. equisimilis (SDSE) M proteins act as collagen-binding adhesins that facilitate acute infection. Moreover, their potential to trigger collagen autoimmunity has been implicated in the pathogenesis of acute rheumatic fever and attributed to a collagen-binding motif called PARF (peptide associated with rheumatic fever...

The conclusions I would draw from this work are merely those stated in a former paper. 1. The results obtained by injections of streptococci are different from those produced by Micrococcus rheumaticus. 2. Micrococcus rheumaticus cannot be regarded as an attenuated streptococcus, nor acute rheumatism as an attenuated streptococcal pyaemia. 3. In uncomplicated cases of acute rheumatism the organ...

conclusions although lap had good performance in early diagnosis of gas, a combination of clinical findings, including tonsillar exudates, petechiae with results of rapid antigen test or culture is necessary for clinician judgment. throat culture is the gold standard test for detecting group a streptococcal infection, but rapid test is a good replacement for culture. objectives the aim of this ...

newborns’ bacterial infections due to group b streptococcus (gbs) happen in two forms including early-onset disease or late-onset disease. in this paper, we report a case of early-onset gbs infection in a male infant. a 22-year-old primigravid woman delivers a term normal looking male infant. nasal flaring, grunting, and poor feeding presented soon after birth. an empiric treatment with intrave...

Sydenham’s chorea is a delayed complication of group Aßhaemolytic streptococcal infections and forms one of the majorcriteria of acute rheumatic fever.It is characterised bychorea, muscular weakness, and a number of neuropsychiatricsymptoms. It is considered to be an autoantibody mediated disorderwith the evidence suggesting that patients with Sydenham’schorea produce antibodies that cross reac...

Streptococcus pyogenes is an important human pathogen and surface structures allow it to adhere to, colonize and invade the human host. Proteins containing leucine rich repeats (LRR) have been identified in mammals, viruses, archaea and several bacterial species. The LRRs are often involved in protein-protein interaction, are typically 20-30 amino acids long and the defining feature of the LRR ...