Objectives: The current preclinical study aimed at appraising the claim of anti diarrheal activity, acute and sub chronic oral toxicity of the polyherbal formulation Entoban to acknowledge its safety and efficacy. Methods: In order to investigate the antidiarrheal activity albino mice were treated with Entoban at doses of 2.5, 5, 10 mg/kg. For evaluation of acute toxicity the animals were treat...

Silver salts and nanosilver (NS) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. Therefore, in this study, the possible dermal toxicity of NS particles and silver nitrate (AgNO3), was tested by determining the serum level of transforming growth factor-β1(TGF-β1) and study on of mouse skin tissue. In this stu...

Abstarct: Use of herbal medicines prevails in rural and urban areas of the world; especially for treating ailments which allopathic medicines fail to treat. Present study was undertaken for the pharmacological and toxicological evaluation of Mucuna pruriens, Cinnamomum zeylanicum, and Myristica fragrans, alone and in combination. The acute toxicity was studied on mice and sub chronic toxicity a...

In the present study, the safety profile of Trichosanthes dioica root was evaluated by acute and sub-chronic toxicity study of the hydro alcoholic extract of T. dioica root (TDA) in Swiss albino mice. The oral median lethal dose (LD ) of TDA was found to be 2800 mg/kg body weight. For sub-chronic toxicity study 50 TDA was administered at the single daily dose of 10 mg/kg for 28 consecutive days...

Berberis vulgaris and berberine, its main component, traditionally have been used for treatment of various disorders. The pharmacological properties of them have been investigated using different in vivo and in vitro models. In spite of beneficial effects of B. vulgaris on different cell lines, there are documents have revealed negative impacts of it on animal and human. In this regards, the de...

The majority of patients affected with nitrofurantoin pulmonary toxicity are elderly women [1]. The proposed mechanism of toxicity is either idiosyncratic oxydant-mediated tissue injury by nitrofurantoin metabolites causing depletion of cellular glutathione (chronic form) or by immunological response induced by nitrofurantoin metabolites acting as heptanes and resulting a hypersensitivity react...

Uvaria chamae is used in the treatment of sickle cell crisis Benin. The aim this work to determine safety roots aqueous extract wistar rats. was obtained by maceration. tests for Acute Oral Toxicity (AOT) and Sub-Chronic (SCT) respectively forced gavage a single dose 2000 mg / Kg 200 body weight 28 days were performed on female Wistar animals, serum creatinine, transaminases number white blood ...

Abstract Background Azadirachta indica , Khaya senegalensis Anogeissus leiocarpus and Tamarindus are important ethnomedicinal plants used for health mitigation since the history of mankind. They discretionarily in folkloric medicine on premise that they natural products devoid synthetic preservatives. However, nature endows with metabolites warding off potential attacks from animals environment...

the mechanism by which lead may cause a perturbotion in the nevous system is through the nitric oxide synthase. in this study the effect of lead acetate on the hippocampal constitutive nitric oxide production was studied. the variation in the nitric oxide production may contribute to physiological lead neurotoxicity in vivo. different concentrations of lead acetate (10-9 to 10-6 m), wre added t...