It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

It is a frequent clinical, and less frequent labora tory, observation that a tumor subjected to a number of sublethal irradiations will gradually acquire radioresistance (5, 11). The usual manifes tation of acquired radioresistance by a tumor is the diminished amount of regression for the same dose, or the increased dose required for an equal amount of regression or for sterilization, as the ra...

BACKGROUND Programmed cell death or apoptosis is an essential process for tissue homeostasis. Hepatocyte apoptosis is a common mechanism to many forms of liver disease. This study was undertaken to test the role of ILK in hepatocyte survival and response to injury using a Jo-2-induced apoptosis model. METHODS For survival experiments, ILK KO and WT mice received a single intraperitoneal injec...

Monarch butterflies (Danaus plexippus) frequently consume milkweed in and near agroecosystems and consequently may be exposed to pesticides like neonicotinoids. We conducted a dose response study to determine lethal and sublethal doses of clothianidin using a 36-h exposure scenario. We then quantified clothianidin levels found in milkweed leaves adjacent to maize fields. Toxicity assays reveale...

Accumulation of phosphatidylserine in the inner leaflet of the plasma membrane is a hallmark of eukaryotes. Sublethal levels of staurosporine and related compounds deplete phosphatidylserine from the plasma membrane and abrogate K-Ras signaling. Here, we report that low-dose staurosporine and related compounds increase sphingomyelin mass. Mass-spectrometry and metabolic tracer analysis revealed...

Enhancement of salt (NaCl) tolerance by pretreatment with sublethal dose (50 mM) of NaCl was investigated in V. radiata seedlings. NaCl stress caused drastic effects on roots compared to shoots. Accompanying reductions in length, number of root hairs and branches, roots became stout, brittle and brown in color. Salt stress caused gradual reduction in chlorophyll, carotenoid pigment contents and...

Angiogenesis is essential for tumor growth and metastasis. Because endothelial cells are genetically stable, they rarely acquire resistance to anticancer modalities, and could, thus, be a suitable target for radiation therapy. Heavy ion radiation therapy has attracted attention as an effective modality for cancer therapy because of its highly lethal effects, but the effects of heavy ion irradia...