نتایج جستجو برای: sustained virological response
تعداد نتایج: 1045619 فیلتر نتایج به سال:
BACKGROUND [corrected] Studies on hepatitis C virus kinetics showed that serum levels of interferon fall 48 h after drug administration, when viral load is increasing again. Previously to the availability of pegylated interferon, daily induction therapy with standard interferon was under evaluation. AIMS To evaluate the safety and efficacy of interferon alpha daily induction regimen in combin...
BACKGROUND The key end point for treatment efficacy in chronic hepatitis C is absence of detectable virus at six months after treatment. However, the incidence of clinical events during long term follow up of patients with sustained virological response is still poorly documented and may differ between the Eastern and Western world. AIMS To assess clinical end points during long term follow u...
BACKGROUND & AIMS On-going risk behaviour can lead to hepatitis C virus (HCV) reinfection following successful treatment. We aimed to assess the incidence of persistent HCV reinfection in a population of people who inject drugs (PWID) who had achieved sustained virological response (SVR) seven years earlier. METHODS In 2004-2006 we conducted a multicentre treatment trial comprising HCV genoty...
UNLABELLED Limited data are available about the efficacy of antiviral treatment in hepatitis C virus (HCV)-associated mixed cryoglobulinemia (MC), especially concerning the long-term effects of HCV eradication. The aim of this study was to evaluate the influence of MC on the virological response and the long-term effects of viral eradication on MC. We prospectively enrolled 424 HCV(+) patients ...
OBJECTIVE To determine the frequency of development of hepatocellular carcinoma in patients with chronic liver disease secondary to hepatitis C who had achieved sustained virological response with Interferon and Ribavirin therapy. STUDY DESIGN Retrospective descriptive study. PLACE AND DURATION OF STUDY Shifa International Hospital, Islamabad, Pakistan, from January 2007 to January 2012. ...
Objective: To determine end treatment and sustained virological response to conventional interferons and ribavirin. Methodology: This descriptive study was conducted from January 2009 to September 2011 at DHQ hospital Dir, KPK, Pakistan. Three hundred and forty-seven patients of chronic hepatitis C aged 18 to 60 years were given conventional Interferons alpha 2a and Ribavirin for six months und...
New factors that influence the viral response in HCV non-genotype 2/3 patients must be identified in order to optimize anti-HCV treatment. This multicenter prospective study evaluates the influence of HCV variability and pharmacological parameters on the virological response of these patients to pegylated interferon α2a (peg-IFN-α2a: 180 µg/week) and ribavirin (RBV; 800-1,200 mg/day) for 48 wee...
BACKGROUND In clinical trials, new oral direct-acting antiviral agent therapies have demonstrated a high sustained virological response rate in patients with hepatitis C virus infection. We aimed to analyze the efficacy and safety data from direct-acting antiviral agent interferon-free therapy in hepatitis C virus infection in a study performed in five different clinical settings in Mexico City...
background: hepatitis c virus (hcv) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. in this study we aimed to evaluate the effects of pegylated interferon alfa-2a (peg-ifn a-2a) in reducing serum alt and eradicating serum hepatitis c virus (hcv) rna in hcv infected polytransfused thalassemic patients. materials and methods: a cohort of 51 hcv-...
CONTEXT Accumulating data propose that active injecting drug users might not differ from the general population in terms of sustained virological response when adherent to therapy for chronic hepatitis C. However, current guidelines contain restrictive recommendations for therapy in this group of patients. OBJECTIVE Therefore, we evaluated a cohort of chronic hepatitis C patients regarding th...
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