BACKGROUND Disseminated fungal infections are common presenting opportunistic infections among AIDS patients in developing countries. Primary prophylaxis with itraconazole has been shown to be effective in northern Thailand. This study aimed to compare the efficacy of fluconazole vs itraconazole as primary prophylaxis for fungal infections in HIV-infected patients. METHODS A retrospective coh...

a major group of drugs that have been approved for the therapy of systemic fungal infections are polyene antibiotics. amphotericin b (amb), one of the polyene antibiotics, has been used to treat serious systemic fungal infections by binding to sterols such as ergosterol in fungal cells membrane, and is believed to form pores in the membrane and create a transmembrane ion-channel. since all euka...

Systemic fungal infection occurs in approximately one per cent of the infants in neonatal intensive care units(l,2). Prematurity, prolonged endotracheal intubation, arterial and central venous catheters, use of broad spectrum antibiotics and steroids, necrotizing enterocolitis and gastrointestinal surgery have been associated with development of invasive fungal infections in these infants(l-3)....

Fungal infections are more common and diverse in the tropics but are also increasingly seen in returning travelers and migrants as international travel becomes easier. They are conventionally classified into superficial, cutaneous, subcutaneous, and systemic mycoses. This article provides an overview of superficial, cutaneous, and subcutaneous mycoses that are more prevalent and/or geographical...

Invasive fungal infections are a major challenge in the management of immunocompromised patients and those with renal dysfunction. These challenges are due to the immense morbidity and mortality in such situations. Also the management strategies for invasive mycosis in patients with renal dysfunction have narrow safety profile and involve high-cost. In this review we will discuss the issues inv...

Species of Candida and Aspergillus remain the most common causes of invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant pathogens. Opportunistic yeast-like fungi and moulds such as Zygomycetes, Fusarium spp. and Scedosporium spp. are increasingly being recognised in patient groups such as those with leukaemia and in bone marrow transplant recipients. R...

Many variables affect the outcome of keratomycosis and systemic fungal infections in animals. These include pathogenicity of the fungal organism(toxins, trophisms, and evasion of host response); previous treatment with topical or systemic corticosteroids, which can have a dramatic negative impact on host defense mechanisms: concurrent systemic illness or immunocompromise: severity/extent of inf...

Infections are an important issue in systemic lupus erythematosus (SLE) patients and account for 30-50% of mortality and morbidity [1-5]. Both cellular and humoral immunity defects [6] and the use of corticosteroids and immunosuppressant agents [7,8] make these patients more susceptible to pathogens. Most infectious processes result from common microorganisms such as bacteria and viruses [9]. I...