interaction of drugs with serum albumin, the most abundant protein in plasma, has a great significance in pharmaceutical sciences. it can affect the biological activity, toxicity, and pharmacokinetics of drugs and design of dosages. determination of the impact of chemical modifications of albumin and its structural changes upon interaction with drugs are very important when drugs bind with albu...

serum albumin is the most abundant protein in blood plasma. its two major roles are maintaining osmoticpressure and depositing and transporting compounds. in this paper albumin-ethanol/water solutionssimulations are carried out by three techniques including monte carlo (mc), molecular dynamic (md) andlangevin dynamic (ld) simulations in aqueous solutions. investigation the energy changes with t...

to investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([pd(phen)(r-gly)]no3, r = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. these drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. human serum albumin is also important for drug d...

background: hypoalbuminemia may be caused by liver disease, nephrotic syndrome, burns, protein-losing entropathy, malnutrition, and metabolic stress. alterations in albumin in metabolic stress such as cardiac surgery have been previously investigated. we studied serum albumin concentration in children with congenital heart disease and also the association of hypoalbuminemia with mortality and m...

To investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([Pd(phen)(R-gly)]NO3, R = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. These drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. Human serum albumin is also ...

Background: Hepatitis B (HB) vaccination is a recommended procedure in all dialysis patients, but its efficacy has not been perfect. In the current study, we aimed to conduct a comprehensive review of the literature to find and pool data of the randomized trials evaluating the impact of serum albumin levels on the immunogenicity of HB vaccination in dialysis patients. Methods: Literature searc...

background: inflammatory process has a substantial contribution in the development of anemia in chronic hemodialysis patients. low serum albumin in hemodialysis patients is considered a marker of inflammation. the present longitudinal study aimed to determine the relationship between low baseline serum albumin and future development of anemia. methods: the population of this study consisted of ...

abstract introduction: diabetes is one of the most common endocrine diseases spreading rapidly in the world. diabetes complications are classified into acute and chronic. non-enzymatic glycosylation of body proteins such as hemoglobin and albumin is the main cause of pathogenesis in chronic complications of diabetes. protein glycosylation is an oxidative reaction. antioxidants such as vitamin c...