The mechanical behavior of soft tissue demonstrates a number of complex features including nonlinearity, anisotropy, viscoelasticity, and growth. Characteristic features of the time-dependent and anisotropic behavior are related to the properties of various components of the tissue such as fibrous collagen and elastin networks, large proteins and sugars attached to these networks, and interstit...

in this paper an automatic examination robot was developed to improve the process of cancer detection, tumor localization and geometrical shape diagnosis. a uniformly distributed compressive load was applied to the top tissue surface and the resultant mechanical stress was measured that was employed for the tumor diagnosis task. the experimental examinations were performed on the soft tissue of...

scaffold design has pivotal role in tissue engineering. in the present study, we modified the surface of electrospun poly(caprolactone) (pcl) nanofibers to improve their compatibility with living medium and to show the potential application of pcl nanofibers as a artificial extracellular matrix using in tissue-engineering. pcl nanofibers were fabricated by electrospinning method. to graft gelat...

There are many tactile devices for indentation examinations to measure mechanical properties of tissue. The purpose of this paper is to develop a portable indentation robotic device to show its usability for measuring the mechanical properties of a healthy abdominal tissue. These measurements will help to develop suitable mathematical models representing abdominal tissue. A 1-DOF portable robot...

Three-dimensional biodegradable porous scaffolds play vital roles in tissue engineering. In this study, a hyaluronic acid-collagen (HA-Coll) sponge with an open porous structure and mechanical behavior comparable to brain tissue was developed. HA-Coll scaffolds with different mixing ratios were prepared by a freeze-drying technique and crosslinked with water-soluble carbodiimide to improve mech...

Present research focuses on different strategies to preserve the degenerated disc. To assure long-term success of novel approaches, favorable mechanical conditions in the disc tissue are essential. To evaluate these, a model is required that can determine internal mechanical conditions which cannot be directly measured as a function of assessable biophysical characteristics. Therefore, the obje...

Understanding the mechanical behavior of human brain is critical to interpret the role of physical stimuli in both normal and pathological processes that occur in CNS tissue, such as development, inflammation, neurodegeneration, aging, and most common brain tumors. Despite clear evidence that mechanical cues influence both normal and transformed brain tissue activity as well as normal and trans...

Although the shortening of smooth muscle at physiological lengths is dominated by an interaction between external forces (loads) and internal forces, at very short lengths, internal forces appear to dominate the mechanical behavior of the active tissue. We tested the hypothesis that, under conditions of extreme shortening and low external force, the mechanical behavior of isolated canine trache...